Skeletal muscle leucine incorporation and testosterone uptake in exercised guinea pigs.

European Journal of Applied Physiology and Occupational Physiology
B M McManusJ Scala

Abstract

We examined the changes induced by daily treadmill exercise on body weights, plantaris muscle weights, plantaris protein concentrations, and L-leucine-4,5-3H incorporation into plantaris muscles of normal and castrated young male guinea pigs and of castrated animals receiving testosterone replacement therapy, and compared the testosterone-1,2-3H uptake by plantaris muscles of trained normal guinea pigs to that of untrained animals. Trained animals exhibited significantly lower body and muscle weights and greater labeled leucine incorporation into sarcoplasmic and myofibrillar proteins but did not show significant changes in protein concentrations or labeled testosterone uptake. The level of physical activity of the young animals studied appeared to be more important than gonadal endocrine function in altering protein metabolism and muscle and body weights. Because hypertrophy did not occur in the trained plantaris muscles, which had elevated rates of labeled leucine incorporation, it appears that the trained animals had a higher muscle protein turnover rate. It seems unlikely that testosterone plays an important role in these activity-related phenomena.

References

May 1, 1971·Australian and New Zealand Journal of Medicine·C J EastmanJ H Casey
Jan 1, 1970·Experientia·S Schiaffino, V Hanzlíková
Apr 1, 1971·The Journal of Clinical Endocrinology and Metabolism·R P KelchR B Jaffe
Jul 1, 1971·The American Journal of Physiology·J A FaulknerD A Lieberman
Mar 1, 1968·The Journal of Cell Biology·A L Goldberg
Nov 1, 1968·Endocrinology·A L Goldberg
Feb 1, 1969·The American Journal of Physiology·E L CrewsR E Shank
Jul 1, 1969·The American Journal of Physiology·F A Short
Jan 1, 1966·Journal of Applied Physiology·J A StevensonJ R Beaton
May 1, 1966·The American Journal of Physiology·E E GordonM Fritts
Nov 1, 1967·The American Journal of Physiology·A L Goldberg
Sep 4, 1967·JAMA : the Journal of the American Medical Association·E E Gordon
Mar 1, 1958·Proceedings of the Society for Experimental Biology and Medicine·M A FINK, C E GARDNER
Aug 1, 1965·Analytical Biochemistry·R PARVINT A VENKITASUBRAMANIAN
Jan 1, 1960·Proceedings of the Society for Experimental Biology and Medicine·C D KOCHAKIAN
Dec 1, 1950·The Journal of Clinical Endocrinology and Metabolism·E P McCULLAGHH W McINTOSH
Nov 1, 1948·The American Journal of Physiology·C D KOCHAKIANM N BARTLETT

❮ Previous
Next ❯

Citations

Jan 1, 1981·European Journal of Applied Physiology and Occupational Physiology·H A WengerT Nihei
Nov 6, 2003·Medicine and Science in Sports and Exercise·Laurie Hoffman-Goetz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Applied Physiology and Occupational Physiology
E A CookJ R Swartman
Internationale Zeitschrift für angewandte Physiologie, einschliesslich Arbeitsphysiologie
L Stumpfhauser, D R Lamb
© 2022 Meta ULC. All rights reserved