Skeletal Muscle Loss during Neoadjuvant Chemotherapy Is an Independent Risk Factor for Postoperative Infectious Complications in Patients with Advanced Esophageal Cancer

Oncology
Masaaki MotooriMasahiko Yano

Abstract

Neoadjuvant therapy followed by surgery has been the standard treatment for advanced esophageal cancer. Severe toxicities may influence body composition, including skeletal muscle mass, and increase postoperative complications. The purpose of this study was to evaluate the influence of sarcopenia, changes in body composition, and adverse events during neoadjuvant chemotherapy (NACT) on postoperative complications in esophageal cancer patients. A total of 83 patients with esophageal cancer undergoing NACT followed by esophagectomy were included. Body composition was assessed before chemotherapy and before esophagectomy. The relationships between postoperative infectious complications and sarcopenia, changes in body composition, and adverse events during NACT were investigated. Univariate analysis revealed that skeletal muscle loss during NACT, but not preoperative sarcopenia, was significantly higher in the complication (+) group. Febrile neutropenia tended to occur frequently in the complication (+) group. Multivariate analysis demonstrated that skeletal muscle loss was the only factor significantly associated with infectious complications (p = 0.029). Among adverse events, febrile neutropenia was significantly associated with ...Continue Reading

Citations

Nov 30, 2019·International Journal of Colorectal Disease·James TankelPetachia Reissman
Apr 7, 2021·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·Piers R BoshierDonald E Low
Jun 20, 2021·Journal of Cachexia, Sarcopenia and Muscle·Han Gyul YoonKyunga Kim
Jul 21, 2021·European Journal of Oncology Nursing : the Official Journal of European Oncology Nursing Society·Yiwei CaoYan Sun

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