Skeletal muscle mass and composition during mammalian hibernation

The Journal of Experimental Biology
Clark J Cotton

Abstract

Hibernation is characterized by prolonged periods of inactivity with concomitantly low nutrient intake, conditions that would typically result in muscle atrophy combined with a loss of oxidative fibers. Yet, hibernators consistently emerge from winter with very little atrophy, frequently accompanied by a slight shift in fiber ratios to more oxidative fiber types. Preservation of muscle morphology is combined with down-regulation of glycolytic pathways and increased reliance on lipid metabolism instead. Furthermore, while rates of protein synthesis are reduced during hibernation, balance is maintained by correspondingly low rates of protein degradation. Proposed mechanisms include a number of signaling pathways and transcription factors that lead to increased oxidative fiber expression, enhanced protein synthesis and reduced protein degradation, ultimately resulting in minimal loss of skeletal muscle protein and oxidative capacity. The functional significance of these outcomes is maintenance of skeletal muscle strength and fatigue resistance, which enables hibernating animals to resume active behaviors such as predator avoidance, foraging and mating immediately following terminal arousal in the spring.

References

Sep 1, 1977·The Journal of Physiology·P Andersen, J Henriksson
Jan 1, 1992·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·G Heldmaier, T Ruf
Jun 1, 1992·Journal of Applied Physiology·D G BellI Jacobs
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·D A KoebelJ M Steffen
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·J M SteffenW K Milsom
Nov 1, 1991·Zeitschrift Für Naturforschung. C, a Journal of Biosciences·B AgostiniW Hasselbach
Sep 1, 1991·The American Review of Respiratory Disease·C ShindohG Supinski
Jan 1, 1990·Journal of Applied Physiology·D B Thomason, F W Booth
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C C PetersonJ Diamond
Jan 1, 1988·Comparative Biochemistry and Physiology. A, Comparative Physiology·C Moreau-HamsanyB Sutter
Jul 1, 1987·Journal of Applied Physiology·D B ThomasonK M Baldwin
Aug 1, 1985·Journal of Applied Physiology·H HoppelerE R Weibel
Feb 1, 1993·Journal of Applied Physiology·G R AdamsG A Dudley
Sep 1, 1995·Respiration Physiology·W D ReidW K Milsom
May 1, 1996·Journal of Applied Physiology·V J CaiozzoK M Baldwin
Jun 20, 1998·Physiological Zoology·I H ChoiH C Shin
Jul 2, 1998·Acta Physiologica Scandinavica·A Y MeigalH Rintamäki
Jul 25, 1998·Physiological Zoology·D B TinkerT D Beck
Aug 28, 1998·European Journal of Applied Physiology and Occupational Physiology·T J CarrollM T McEniery
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·C ZancanaroS Fakan
Dec 3, 1999·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·J C OpazoF Bozinovic
Jul 7, 2000·Muscle & Nerve·J L Andersen, P Aagaard
Jul 18, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·C L Buck, B M Barnes
Aug 11, 2000·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·M H KimI H Choi
Mar 10, 2001·Nature·H J HarlowP A Iaizzo
Mar 29, 2001·Proceedings of the National Academy of Sciences of the United States of America·L F MichaelB M Spiegelman
Jun 13, 2001·American Journal of Physiology. Cell Physiology·T A HornbergerK A Esser
Oct 20, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·F van Breukelen, S L Martin
Feb 14, 2002·Physiological Genomics·Michael J BuckMatthew T Andrews
Mar 15, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J PrendergastRandy J Nelson
Aug 16, 2002·Physiological Genomics·L Elaine Epperson, Sandra L Martin
Nov 1, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·R Thomas JagoeAlfred L Goldberg
Dec 7, 2002·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Keith BaarJohn O Holloszy
Jul 5, 2003·Physiological Reviews·Darrell E GollJinyang Cong

❮ Previous
Next ❯

Citations

Nov 2, 2016·The Journal of Experimental Biology·Emily M BruntPatricia A Wright
Sep 2, 2016·The Journal of Experimental Biology·Beau D Reilly, Craig E Franklin
Nov 16, 2019·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Hui ChangYunfang Gao
Feb 18, 2017·World Journal of Gastroenterology : WJG·Claudia SisaMatteo Cerri
May 16, 2017·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Huan-Xin HuYun-Fang Gao
Dec 1, 2019·The Journal of Experimental Biology·Scott Medler
Dec 21, 2018·Pflügers Archiv : European journal of physiology·A ChoukèrG Heldmaier
Jul 25, 2018·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·Hui ChangYun-Fang Gao
Oct 31, 2020·Frontiers in Physiology·Traver J WrightMelinda Sheffield-Moore
Nov 25, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Jihui ZhangXiaobing Wu
Feb 9, 2021·Frontiers in Physiology·Sylvain GiroudKenneth B Storey
Mar 9, 2021·Frontiers in Physiology·Fabrice BertileSylvain Giroud
Apr 4, 2021·International Journal of Molecular Sciences·Bruna Tereza Thomazini ZanellaMaeli Dal-Pai-Silva
Jun 19, 2021·Neuroscience and Biobehavioral Reviews·Matteo CerriRoberto Amici

❮ Previous
Next ❯

Related Concepts

Related Feeds

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.