Skeletal muscle metabolism in experimental heart failure

Journal of Molecular and Cellular Cardiology
P BernocchiR Ferrari

Abstract

We studied peripheral skeletal muscle metabolism in monocrotaline-treated rats. Two distinct groups emerged: a percentage of the animals developed ventricular hypertrophy, with no signs of heart failure (compensated group), whilst others, besides ventricular hypertrophy, developed the syndrome of congestive heart failure (CFH group). Oxidative metabolism and redox cellular state were expressed in terms of creatine phosphate, purine (ATP, ADP and AMP) and pyridine (NAD and NADH) nucleotides tissue content. Skeletal muscles with different metabolism were studied: (a) Soleus (oxidative), (b) extensor digitorium longus (glycolytic) and tibialis anterior (oxidative and glycolytic). The results showed that in CFH animals a decreased high-energy phosphates content occurs in the soleus and extensor digitorum longus, but not in the tibialis anterior. In the soleus. ATP declined from 20.31 +/- 2.5 of control group to 9.55 +/- 0.61 mumol/g dry wt. while in the extensor digitorum longus ATP declined from 30.92 +/- 2.68 to 22.7 +/- 1.54 mumol/g dry wt. In both these muscles, a shift of NAD/NADH couple towards oxidation was also observed (from 26.58 +/- 3.34 to 6.95 +/- 0.97 and from 18.88 +/- 3.43 to 10.57 +/- 1.61, respectively). These alt...Continue Reading

Citations

May 13, 1998·Acta Physiologica Scandinavica·P K LundeO M Sejersted
Jun 20, 2001·Acta Physiologica Scandinavica·P K LundeO M Sejersted
Dec 9, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Y HellstenJ Bangsbo
Mar 16, 2002·Journal of Applied Physiology·Issei ShiotaniMasatsugu Hori
Jun 19, 2001·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·W G AschenbachL B Gladden

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