PMID: 6540677Jan 1, 1984Paper

Skeletal muscle metabolism of sea-level natives following short-term high-altitude residence

European Journal of Applied Physiology and Occupational Physiology
A J YoungJ T Maher

Abstract

The influence of short-term high-altitude (HA) residence on intramuscular pH and skeletal muscle enzyme activity of sea-level (SL) residents was investigated. Vastus lateralis muscle samples were obtained by biopsy from rested subjects (n = 5) at SL (50 m) and on the 18th day of HA residence (4,300 m) for determination of glycogen phosphorylase, hexokinase, malate dehydrogenase, and total lactate dehydrogenase activities. A second group of subjects (n = 6) performed cycle exercise of the same absolute intensity (mean +/- SE = 195 +/- 5 W) at SL and on the 15th day of residence at HA. Before and immediately after exercise, vastus lateralis muscle samples were obtained for the determination of intramuscular pH, and venous blood was obtained for determination of lactate concentration. The first group of subjects showed no significant changes in skeletal muscle enzyme activity after 18 days at HA. The second group of subjects were instructed to exercise for exactly 30 min, and all but one could complete the entire bout at SL. However, at HA, none could continue 30 min, and time to exhaustion (mean +/- SE) was 11.9 +/- 1.6 min. Resting intramuscular pH was not significantly different after HA residence as compared to SL. The fall in...Continue Reading

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Citations

Jan 1, 1993·European Journal of Applied Physiology and Occupational Physiology·B W Rosser, P W Hochachka
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·B Kayser
Jan 1, 1988·European Journal of Applied Physiology and Occupational Physiology·N TerradosL Kaijser
Jan 1, 1990·Brain Research Bulletin·A IshiharaK Itoh
Nov 13, 2001·American Journal of Respiratory and Critical Care Medicine·E DoussetY Jammes
Dec 5, 2014·Extreme Physiology & Medicine·James A Horscroft, Andrew J Murray
Oct 30, 2001·High Altitude Medicine & Biology·O Mathieu-Costello
Dec 1, 1990·Experientia·H HoppelerP Cerretelli
Sep 17, 2009·Cellular and Molecular Life Sciences : CMLS·Carsten LundbyPaul Robach
May 31, 2011·Respiratory Physiology & Neurobiology·G ValliP Palange
Aug 25, 2015·Cellular and Molecular Life Sciences : CMLS·F B FavierH Benoit
Jul 27, 2001·Acta Physiologica Scandinavica·B GrassiP Cerretelli
Apr 23, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Nikolai B NordsborgCarsten Lundby
Feb 5, 2000·Journal of Applied Physiology·H GreenD McKenzie
May 18, 2001·Journal of Applied Physiology·T L Clanton, P F Klawitter
Oct 26, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·H GreenM Johnson

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