Skeletal muscle mitochondrial myopathy as a cause of exercise intolerance in a horse

Muscle & Nerve
S J ValbergS DiMauro

Abstract

Although exertional myopathies are commonly recognized in horses, specific etiologies have not been identified. This is the first report in the horse of a deficiency of Complex I respiratory chain enzyme associated with profound exercise intolerance. Physical examination, routine blood tests, endoscopy, and ultrasonograms of the heart and iliac arteries were unremarkable. With slow, incremental exercise (speeds 1.5-7 m/s), the Arabian mare showed a marked lactic acidosis, increased mixed venous PVO2, and little change in oxygen consumption. Muscle biopsies contained large accumulations of mitochondria with bizarre cristae formations. Biochemical analyses revealed a very low activity of the first enzyme complex in the mitochondrial respiratory chain (NADH CoQ reductase). The exercise intolerance and muscle stiffness in this horse were attributed to a profound lactic acidosis resulting from impaired oxidative energy metabolism during exercise.

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Citations

Jan 25, 1996·The New England Journal of Medicine·H Stoicheff, C Vital
Apr 4, 2013·Journal of the American Veterinary Medical Association·Holly E BedfordTroy N Trumble
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Aug 26, 2018·Journal of Bioenergetics and Biomembranes·Irene TosiDominique-Marie Votion

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