Skeletal muscle morphology, metabolism and function in smokers and non-smokers. A study on smoking-discordant monozygous twins

Acta Physiologica Scandinavica
Lars Larsson, J Orlander

Abstract

Differences in skeletal muscle characteristics between smokers and non-smokers have been demonstrated in a previous study ( Orlander , J. et al. 1979, Acta Physiol Scand 107:39-46). In order to decide whether these differences had a genetical background, six pairs of smoking-discordant monozygous twins were studied with respect to muscle (vastus lateralis) morphology, metabolism and function. The percentage type I fibres was lower in the smokers, who also had smaller diameters of this fibre type. Cytochrome oxidase activity was decreased in the smokers. No differences were seen for other enzymes of energy metabolism, capillary density, isometric or dynamic strength, or short-term muscular endurance. The non-smokers tended to be more physically active. In four ex-smoker/non-smoker pairs, no significant differences were found for the investigated parameters. It was concluded, that the difference in fibre type distribution is not due to a hereditary predisposition to take up smoking. Furthermore, the small difference in physical activity level is an unlikely cause. Thus, smoking per se appears to be the most plausible explanation for the difference in fibre type distribution and associated muscle characteristics. No definitive con...Continue Reading

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Citations

Feb 16, 2007·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Prema B RapuriLynette M Smith
Mar 1, 1983·Acta Physiologica Scandinavica·L Larsson
Jul 31, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Vladimir T BasicSamy M Abdel-Halim
Apr 24, 2010·American Journal of Respiratory and Critical Care Medicine·Esther BarreiroUNKNOWN ENIGMA in COPD Project
Nov 8, 2008·American Journal of Respiratory Cell and Molecular Biology·Harry R GoskerAnnemie M W J Schols
May 3, 2014·American Journal of Respiratory and Critical Care Medicine·François MaltaisUNKNOWN ATS/ERS Ad Hoc Committee on Limb Muscle Dysfunction in COPD
Jun 19, 2008·European Journal of Applied Physiology·Rob C I WüstHans Degens
Jun 17, 2003·Journal of Toxicology. Clinical Toxicology·Francesc CardellachOscar Miró
Jan 13, 2015·American Journal of Respiratory and Critical Care Medicine·Hans DegensHieronymus W H van Hees
Feb 17, 2017·Occupational Medicine·A G SiddallK A Stokes
Oct 27, 2016·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C D C NevesV A Mendonça
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Mar 15, 2019·Journal of Cardiopulmonary Rehabilitation and Prevention·Jéssica FonsecaFabio Pitta
Jan 23, 2020·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Tom Tanjeko AjimeGhislaine Gayan-Ramirez
Sep 13, 2003·Pharmacology & Toxicology·Jose-Ramon AlonsoOscar Miró
May 24, 2015·American Journal of Physiology. Lung Cellular and Molecular Physiology·K KrügerF C Mooren
Jul 17, 2020·Multidisciplinary Respiratory Medicine·Mohammad Z DarabsehHans Degens
Nov 3, 2021·Journal of Cachexia, Sarcopenia and Muscle·Trace ThomeRussell T Hepple

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