Skeletal muscle pathways of contraction-enhanced glucose uptake

International Journal of Sports Medicine
J M SantosJ A Duarte

Abstract

Muscle contraction acutely increases glucose transport in both healthy and type 2 diabetic individuals. Since glucose uptake during muscle contraction has been observed in the absence of insulin, the existence of an insulin-independent pathway has been suggested to explain this phenomenon. However, the exact mechanism behind the translocation of GLUT4 vesicles through the sarcolemma during muscle contraction is still unknown. Some substances, such as AMPK and calcium activated proteins, have been suggested as potential mediators but the exact mechanisms of their involvement remain to be elucidated. A hypothetical convergence point between the insulin cascade and the potential pathways triggered by muscle contraction has been suggested. Therefore, the earliest concept that two different routes exist in skeletal muscle has been progressively modified to the notion that glucose uptake is induced by muscle contraction via components of the insulin pathway. With further consideration, increased glucose uptake and enhanced insulin sensitivity observed during/after exercise might be explained by a metabolic- and calcium-dependent activation of several intermediate molecules of the insulin cascade. This paper aimed to review the litera...Continue Reading

Citations

Mar 2, 2011·Wiener medizinische Wochenschrift·Christian BrinkmannKlara Brixius
Apr 9, 2011·Biotechnology Letters·S PasseyM P Lewis
Dec 2, 2011·Journal of Strength and Conditioning Research·Sérgio R MoreiraHerbert G Simões
Apr 8, 2014·Advances in Pharmacological Sciences·Manish KumarSiva Hemalatha
Oct 21, 2015·Metabolism: Clinical and Experimental·Júlia Matzenbacher Dos SantosSandra Aparecida Benite-Ribeiro
Aug 28, 2009·Cell Biochemistry and Function·Eduardo KokubunHorst Haebisch
Nov 30, 2011·Cell Biochemistry and Function·J M dos SantosJ A Duarte
Jun 7, 2013·Cell Biochemistry and Function·Sandra Aparecida Benite-RibeiroJosé Alberto Ramos Duarte
Feb 6, 2010·Clinical Physiology and Functional Imaging·Peter HovindJens Bülow
Mar 19, 2009·Orvosi hetilap·Péter Apor
Apr 8, 2014·Medical Hypotheses·Júlia M SantosSandra A Benite-Ribeiro
Jul 4, 2016·Medical Hypotheses·Sandra Aparecida Benite-RibeiroJúlia Matzenbacher Santos
Oct 22, 2016·Clinical Hemorheology and Microcirculation·Helena Lenasi, Markos Klonizakis
Mar 12, 2015·Anais Da Academia Brasileira De Ciências·Rafael O AlvimPaulo C J L Santos
Jun 27, 2017·Scandinavian Journal of Medicine & Science in Sports·C BrinkmannK Brixius
Aug 18, 2020·Molecular Biology Reports·Sandra Aparecida Benite-RibeiroJulia Matzenbacher Dos Santos
Apr 22, 2018·Molecular and Cellular Biochemistry·Julia Matzenbacher Dos SantosSandra Aparecida Benite-Ribeiro
Jun 14, 2019·Journal of Diabetes Research·Julia M Dos SantosRoberta H Mendes
Nov 14, 2020·The Journal of Clinical Endocrinology and Metabolism·Waris WongpipitStephen Heung-Sang Wong
Aug 8, 2020·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Tomaz MaršNataša Nikolić

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