Skeletal Muscle Pump Function Is Associated With Exercise Capacity in Patients With Heart Failure

Circulation Journal : Official Journal of the Japanese Circulation Society
Toru KondoToyoaki Murohara

Abstract

Skeletal muscle pump function may play a key role in maintaining cardiac output (CO), because of the lack of cardiac contractility reserve during incremental exercise in heart failure (HF) patients. We aimed to investigate the relationship between lower leg pump function and surrogate measures of CO during cardiopulmonary exercise testing (CPX) in HF patients.Methods and Results:Consecutive cardiac patients referred for CPX had their lower leg ejection fraction (LgEF) measured using strain gauge plethysmography as a marker of skeletal muscle pump function. We analyzed 88 patients, including 65 HF patients and 23 control subjects. Unlike the control subjects, LgEF correlated with peak oxygen consumption (V̇O2) and peak oxygen (O2) pulse (peak V̇O2: r=0.280, P=0.024; peak O2 pulse: r=0.540, P<0.001) in HF patients. Significant relationships among LgEF, peak V̇O2, and peak O2 pulse were observed in HF patients with reduced EF (peak V̇O2: r=0.367, P=0.026; peak O2 pulse: r=0.658, P<0.001), whereas LgEF in HF patients with preserved EF showed a weak correlation only with peak O2 pulse (r=0.407, P=0.032). LgEF was selected as an independent determinant of peak V̇O2 (β=0.187, P=0.036) and peak O2 pulse (β=0.520, P<0.001) in HF patient...Continue Reading

References

Apr 1, 1985·The American Journal of Cardiology·J SzlachcicJ Tubau
Jun 1, 1994·European Heart Journal·M VolterraniA J Coats
Jul 27, 2000·Medicine and Science in Sports and Exercise·M M BammanG R Hunter
Nov 15, 2000·Circulation·A N NicolaidesUNKNOWN Union Internationale de Phlebologie at the Abbaye des Vaux de Cernay
Jul 15, 2003·Journal of Applied Physiology·Ali A EhsaniJohn O Holloszy
Jan 14, 2004·Journal of Vascular Surgery·Frank T PadbergSue Ann Sisto
Nov 16, 2005·Journal of the American College of Cardiology·Marco GuazziRoss Arena
Jan 12, 2008·Journal of the American Society of Echocardiography : Official Publication of the American Society of Echocardiography·Erwan DonalAndré Denjean
Mar 26, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Mark J HaykowskyDalane W Kitzman
Apr 11, 2014·The New England Journal of Medicine·Bertram PittUNKNOWN TOPCAT Investigators
Jun 14, 2014·Heart Failure Reviews·Valentina CarubelliCarlo Lombardi
Jul 25, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Michio NakanishiYoichi Goto
Apr 14, 2016·European Journal of Heart Failure·María T VidánHéctor Bueno

❮ Previous
Next ❯

Citations

Jan 22, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Mohamed RadyKrunoslav Michael Sveric
Jan 27, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Takeshi OnoueYutaka Otsuji
Aug 29, 2019·ESC Heart Failure·Toru KondoToyoaki Murohara
Mar 11, 2020·Heart and Vessels·Hiroshi TashiroToyoaki Murohara

❮ Previous
Next ❯

Related Concepts

Related Feeds

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.