Skeletal muscle tissue in movement and health: positives and negatives

The Journal of Experimental Biology
Stan L Lindstedt

Abstract

The history of muscle physiology is a wonderful lesson in 'the scientific method'; our functional hypotheses have been limited by our ability to decipher (observe) muscle structure. The simplistic understanding of how muscles work made a large leap with the remarkable insights of A. V. Hill, who related muscle force and power to shortening velocity and energy use. However, Hill's perspective was largely limited to isometric and isotonic contractions founded on isolated muscle properties that do not always reflect how muscles function in vivo. Robert Josephson incorporated lengthening contractions into a work loop analysis that shifted the focus to dynamic muscle function, varying force, length and work done both by and on muscle during a single muscle work cycle. It became apparent that muscle is both a force generator and a spring. Titin, the missing filament in the sliding filament model, is a muscle spring, which functions very differently in cardiac versus skeletal muscle; its possible role in these two muscle types is discussed relative to their contrasting function. The good news for those of us who choose to work on skeletal muscle is that muscle has been reluctant to reveal all of its secrets.

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Citations

Nov 5, 2016·Annual Review of Physiology·Stan Lindstedt, Kiisa Nishikawa
Mar 11, 2017·Frontiers in Physiology·Michael O Harris-LoveBrian M Hoover
Feb 16, 2017·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Evan Pollock-Tahiri, Marius Locke
Sep 25, 2017·The Journal of Experimental Biology·Anthony L Hessel, Kiisa C Nishikawa
Jan 23, 2016·The Journal of Experimental Biology·Kiisa Nishikawa
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Apr 2, 2020·Journal of Translational Medicine·Roberto RoklicerPatrik Drid
Feb 25, 2017·Frontiers in Physiology·Anthony L HesselKiisa C Nishikawa
Aug 2, 2017·Annals of Saudi Medicine·Pejana RastovicMaja Pandza
Aug 28, 2020·Frontiers in Physiology·Erika E Rodriguez-TorresIsmael Jiménez-Estrada
Nov 7, 2020·European Journal of Applied Physiology·Nikos V MargaritelisVassilis Paschalis
Mar 25, 2019·Journal of Human Evolution·Scott W SimpsonSileshi Semaw

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