Skeletal muscle weakness, exercise tolerance and physical activity in adults with cystic fibrosis

The European Respiratory Journal
Thierry TroostersL Dupont

Abstract

The aim of the present study was to investigate the prevalence of muscle weakness and the importance of physical inactivity in cystic fibrosis (CF), and its relationship to exercise tolerance and muscle strength. Exercise tolerance, skeletal and respiratory muscle strength were studied in a group of 64 adults with CF (age 26+/-8 yrs, FEV(1 % predicted) 65+/-19) and in 20 age-matched controls. Physical activity (PA) was assessed in 20 patients and all controls. Quadriceps muscle weakness was present in 56% of the patients. Peak oxygen uptake and 6-min walking distance were below normal in 89 and 75% of patients, respectively. Respiratory muscle strength was normal. The differences remained after correcting for PA. Quadriceps force was correlated to the 6-min walking distance but not to peak oxygen uptake. "Mild" PA (>3 metabolic equivalents (METS)) and the number of steps overlapped with controls, but CF patients had less moderate PA (>4.8 METS). Moderate PA was related to peak oxygen uptake and quadriceps force. Skeletal muscle weakness and exercise intolerance are prevalent in cystic fibrosis. Physical inactivity is a factor significantly contributing to exercise tolerance and skeletal muscle force in adults with cystic fibros...Continue Reading

Citations

Mar 19, 2013·Respiratory Research·Pauline Barbera van de Weert-van LeeuwenJeffrey Matthijn Beekman
Apr 23, 2013·Respiratory Research·Chris BurtinThierry Troosters
Feb 1, 2014·Respiratory Medicine·Pauline B van de Weert-van LeeuwenHubertus G M Arets
Jun 3, 2014·BMC Pulmonary Medicine·Jean PastréBenoit Wallaert
Oct 22, 2013·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Susana AznarAlejandro Lucia
May 31, 2014·Clinics in Chest Medicine·Carolyn L RochesterRebecca H Crouch
Jul 30, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Judy BradleyUNKNOWN Exercise Working Group European CF Society
Feb 5, 2011·Chest·Sergio Tejero GarcíaIgnacio Gómez de Terreros
Jun 3, 2015·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Mathieu GruetSamuel Verges
Oct 17, 2012·Paediatric Respiratory Reviews·Athari Almajed, Larry C Lands
Oct 1, 2013·Respiratory Medicine·Bente FriskEinar Thorsen
Dec 31, 2015·Respirology : Official Journal of the Asian Pacific Society of Respirology·Narelle S CoxAnne E Holland
Nov 17, 2010·Journal of Electromyography and Kinesiology : Official Journal of the International Society of Electrophysiological Kinesiology·J M VallierJ Brisswalter
Apr 21, 2010·Revue des maladies respiratoires·P-R Burgel
Dec 2, 2015·American Journal of Respiratory and Critical Care Medicine·Carolyn L RochesterUNKNOWN ATS/ERS Task Force on Policy in Pulmonary Rehabilitation
Oct 8, 2013·Respiratory Medicine·Daniela SaviPaolo Palange
Oct 26, 2013·Respiratory Medicine·Clémence MartinPierre-Régis Burgel
Oct 30, 2013·Pediatric Pulmonology·Greg D WellsFelix Ratjen
Dec 24, 2013·Archives of Physical Medicine and Rehabilitation·Anderson Alves de CamargoSimone Dal Corso
Nov 26, 2015·Scandinavian Journal of Medicine & Science in Sports·B K Pedersen, B Saltin
Apr 6, 2016·Heart & Lung : the Journal of Critical Care·Erik H Van ItersonEric M Snyder
Mar 12, 2015·Experimental Physiology·Melissa L EricksonRyan A Harris
Jan 18, 2012·Respiratory Physiology & Neurobiology·Charles C ReillyGerrard F Rafferty
Jan 10, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Bradley S QuonChristopher H Goss
Jan 11, 2014·Physiotherapy Theory and Practice·Tatiana Rafaela Lemos LimaAgnaldo José Lopes
May 15, 2015·BMC Pulmonary Medicine·Judy M BradleyBrenda O'Neill
Apr 19, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Brenda M ButtonAnne E Holland
Jul 9, 2014·Respiratory Medicine·Paula Maria Eidt RovedderPaulo de Tarso Roth Dalcin
Nov 23, 2011·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Hervé Laborde-CastérotDominique Hubert
Jan 10, 2012·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Jason WieboldtNicholas S Hopkinson
Nov 6, 2010·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·Courtney M WheatleyEric M Snyder
May 26, 2009·Respiratory Medicine·Tiffany Jane DwyerPeter Thomas Patrick Bye
May 23, 2016·Revue des maladies respiratoires·C Le GalG Reychler
Jun 19, 2016·Journal of Cystic Fibrosis : Official Journal of the European Cystic Fibrosis Society·N DecorteB Wuyam
Sep 27, 2016·Medicine and Science in Sports and Exercise·Nadia BeaudoinYves Berthiaume
Jul 4, 2017·Journal of Cardiopulmonary Rehabilitation and Prevention·Daniel Stevens, Heather F Neyedli

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.