Skeletal standardized uptake values obtained by quantitative SPECT/CT as an osteoblastic biomarker for the discrimination of active bone metastasis in prostate cancer

European Journal of Hybrid Imaging
Ichiei KujiMasafumi Oyama

Abstract

To investigate the improvement of prognostication of active bone metastatic burden by discriminating bone metastases from degenerative changes in hot foci, using skeletal standardized uptake values (SUVs) by quantitative bone single photon emission tomography/computed tomography (SPECT/CT) in patients with prostate cancer. We investigated 170 patients with prostate cancer who underwent skeletal quantitative SPECT/CT using 99mTc-methylene-diphosphonate (MDP), through conjugate gradient reconstruction with tissue zoning, attenuation, and scatter corrections applied, called as CGZAS reconstruction, in a retrospective cohort study. The maximum, peak, and average SUVs (SUVmax, SUVpeak, and SUVave, respectively) were obtained for visually normal thoracic (T; n = 100) and lumbar (L; n = 140) vertebral bodies as controls, as well as for bone metastases (n = 126) and degenerative changes (n = 114) as hot foci. They were also correlated with age, body-weight, height, biochemistry data, and extent of disease (EOD). Discrimination accuracy of the SUVs for bone metastases in hot foci was evaluated by a patient-based and lesion-based receiver-operator characteristic curve (ROC) analysis. The skeletal SUVmax was 7.58 ± 2.42 for T, 8.12 ± 12.2...Continue Reading

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Citations

Dec 28, 2019·BMC Musculoskeletal Disorders·Flavian TabottaMarie Nicod Lalonde
Jul 1, 2020·EJNMMI Research·Noriaki MiyajiMasahisa Onoguchi
May 3, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Tomohiko YamaneIchiro Matsunari
Jul 13, 2019·The Quarterly Journal of Nuclear Medicine and Molecular Imaging : Official Publication of the Italian Association of Nuclear Medicine (AIMN) [and] the International Association of Radiopharmacology (IAR), [and] Section of the Society of Radiopharmaceutica·Stijn De SchepperTorsten Kuwert
Oct 22, 2019·Nihon Hoshasen Gijutsu Gakkai zasshi·Akinobu KitaToshiki Adachi
Jun 23, 2020·Nihon Hoshasen Gijutsu Gakkai zasshi·Yasushi Yamamoto
Jun 25, 2019·Nuclear Medicine and Molecular Imaging·Won Woo Lee, UNKNOWN K-SPECT Group
Jun 13, 2018·Nuclear Medicine Communications·Masakazu TsujimotoHiroshi Toyama
Jan 6, 2021·Annals of Nuclear Medicine·Tomohiko YamaneIchiei Kuji
Jan 19, 2021·Annals of Nuclear Medicine·Takahiro KonishiSeigo Kinuya
Feb 24, 2021·Physical and Engineering Sciences in Medicine·Masakazu TsujimotoHiroshi Toyama
May 24, 2020·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Helmut DittmannChristian la Fougère
May 3, 2019·European Journal of Hybrid Imaging·James C RossJohn Dickson
Jul 8, 2021·Science Progress·Masaru IshiharaTakayuki Shibutani
Aug 19, 2021·Nuclear Medicine Communications·Martin HavelMartin Formanek

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Methods Mentioned

BETA
biopsy
X-ray

Software Mentioned

GraphPad
Prism
SPSS

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