Skeletal tissue, a viable option in forensic toxicology? A view into post mortem cases

Forensic Science International : Synergy
Michiel VandenboschEva Cuypers

Abstract

Blood analysis is the golden standard in the field of forensic toxicology. However, when extended decomposition of the remains has occurred, alternative matrices are required. Skeletal tissue may provide an appropriate sample of choice since it is very resistant to putrefaction. However, today, the absence of reference data of drug concentrations in skeletal tissue poses a problem to meaningfully and reliably conduct toxicological testing on human skeletal material. The present study investigates the viability of skeletal tissue as an alternative matrix to evaluate xenobiotic consumption in legal cases. Blood, bone tissue and bone marrow of different forensic cases were screened for 415 compounds of forensic interest. Afterwards, methadone, clomipramine, citalopram and their respectively metabolites positive samples were quantified using fully validated methods. Sample preparation was carried out by SPE (whole blood and bone marrow), methanol extraction (bone sections) or protein precipitation (whole blood). All samples were analyzed using liquid chromatography coupled to a triple quad mass spectrometer. Multiple drugs were successfully identified in all sampled matrices. In bone (marrow) not as many substances were detected as...Continue Reading

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Citations

Sep 16, 2020·Analytical and Bioanalytical Chemistry·Michiel VandenboschMartina Marchetti-Deschmann
Sep 5, 2021·Journal of Analytical Toxicology·Michiel VandenboschEva Cuypers
Oct 1, 2021·International Journal of Legal Medicine·Théo WillemanVirgine Scolan

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