PMID: 6106785Sep 27, 1980Paper

Skeletal uptake of diphosphonate. Method for prediction of post-menopausal osteoporosis

Lancet
I FogelmanR Lindsay

Abstract

24-h whole-body retention (WBR) of diphosphonate (a sensitive indicator of skeletal metabolism) was measured in 37 oophorectomised women. 14 women had been prescribed oestrogen supplements and 3 of these had defaulted from therapy. For the study group there was a significant correlation between WBR and both the rate of bone loss as measured by photonabsorptiometry (r = 0.7, p ¿ 0.001) and urinary hydroxyproline (r = 0.53, p < 0.001). The oestrogen-treated group had significantly lower values for WBR and rate of bone loss than the untreated group (p < 0.01, p < 0.01 respectively) indicating suppressed skeletal metabolism. However, the highest values were found in those who had defaulted from oestrogen therapy suggesting a rebound period of accelerated skeletal metabolism and bone loss. There was a significant negative correlation between WBR and oestrogen dosage (r = 0.75, p < 0.02) suggesting that it may be possible to adjust the dosage for optimal skeletal metabolic activity. WBR of diphosphonate provides a simple and sensitive measure of skeletal metabolism which correlates well with conventional measurements of bone loss. WBR may be useful in the screening and identification of women who have increased bone turnover just aft...Continue Reading

Citations

Feb 1, 1990·Calcified Tissue International·D B Kimmel, T J Wronski
Dec 1, 1986·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K ThomsenC Christiansen
Apr 1, 1984·Scandinavian Journal of Clinical and Laboratory Investigation·L HyldstrupI Transbøl
Jun 1, 1988·Scandinavian Journal of Clinical and Laboratory Investigation·L HyldstrupI Transbøl
Apr 1, 1982·Scottish Medical Journal·I FogelmanD H Lawson
Jan 1, 1991·Calcified Tissue International·L V Avioli
Jun 1, 1987·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·K ThomsenP Rødbro
Oct 1, 1987·Seminars in Nuclear Medicine·J G McAfee
Aug 9, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Zhonghua XuHaoyu Yang

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