PMID: 44235Dec 1, 1979

SK&F 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade

Clinical Science
E M TaylorR A Slater

Abstract

1. The properties of a new antihypertensive agent, SK&F 92657, DL-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine, have been studied. 2. The compound caused a sustained fall in blood pressure in several species as a result of precapillary vasodilatation, particularly in the renal and coronary vasculatures. 3. The beta-adrenoreceptor-blocking actions of SK&F 92657 prevent reflex cadiac stimulation.

References

Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·F Gross
Mar 1, 1980·British Journal of Clinical Pharmacology·J G Collier, D W Pitcher
Jan 1, 1986·Clinical and Experimental Pharmacology & Physiology·J F Marwood, G S Stokes
Jan 1, 1990·European Journal of Clinical Pharmacology·A G Dupont
Jan 1, 1982·British Journal of Clinical Pharmacology·F Gross
Dec 1, 1983·British Journal of Clinical Pharmacology·W M EdmondstoneD M Denison
Oct 1, 1981·British Journal of Clinical Pharmacology·W M EdmonstoneW L Burland
May 1, 1982·British Journal of Clinical Pharmacology·D W PitcherJ R Trounce

Related Concepts

Myocardial Contraction
Diastolic Blood Pressure
Kidney
Right Atrial Structure
Pulmonary Vascular Resistance
Novodrin
Hypertensive Disease
Beta-adrenergic receptor
Vascular Endothelium-Dependent Relaxation
Vasoactive Antagonists

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