PMID: 44235Dec 1, 1979

SK&F 92657, a novel antihypertensive acting by precapillary vasodilatation and beta-adrenoreceptor blockade

Clinical Science
E M TaylorR A Slater


1. The properties of a new antihypertensive agent, SK&F 92657, DL-3-[2-(3-t-butylamino-2-hydroxypropoxy)phenyl]-6-hydrazinopyridazine, have been studied. 2. The compound caused a sustained fall in blood pressure in several species as a result of precapillary vasodilatation, particularly in the renal and coronary vasculatures. 3. The beta-adrenoreceptor-blocking actions of SK&F 92657 prevent reflex cadiac stimulation.


Jan 1, 1982·Clinical and Experimental Hypertension. Part A, Theory and Practice·F Gross
Mar 1, 1980·British Journal of Clinical Pharmacology·J G Collier, D W Pitcher
Jan 1, 1986·Clinical and Experimental Pharmacology & Physiology·J F Marwood, G S Stokes
Jan 1, 1990·European Journal of Clinical Pharmacology·A G Dupont
Jan 1, 1982·British Journal of Clinical Pharmacology·F Gross
Dec 1, 1983·British Journal of Clinical Pharmacology·W M EdmondstoneD M Denison
Oct 1, 1981·British Journal of Clinical Pharmacology·W M EdmonstoneW L Burland
May 1, 1982·British Journal of Clinical Pharmacology·D W PitcherJ R Trounce

Related Concepts

Myocardial Contraction
Diastolic Blood Pressure
Right Atrial Structure
Pulmonary Vascular Resistance
Hypertensive Disease
Beta-adrenergic receptor
Vascular Endothelium-Dependent Relaxation
Vasoactive Antagonists

Related Feeds

Antihypertensive Agents: Mechanisms of Action

Antihypertensive drugs are used to treat hypertension (high blood pressure) which aims to prevent the complications of high blood pressure, such as stroke and myocardial infarction. Discover the latest research on antihypertensive drugs and their mechanism of action here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.