Skin - a vast organ with immunological function (Review)

Experimental and Therapeutic Medicine
Minela Aida MaranducaIonela Lacramioara Serban

Abstract

The skin is an organ with multiple functions, where important inflammatory and immunological processes take place. The integrity of the skin barrier is necessary for it to fulfill its roles. An intact skin barrier requires a physiological keratinization process, but also a normal cutaneous microbial flora. Any change in the proliferation and differentiation of keratinocytes entails the disruption of the skin barrier and the triggering of inflammatory and immunological processes at this level, in response to the aggression of external pathogens. Also, there are several specialised immune cells in the skin (Langerhans cells, T regulator cells, T helper cells), that maintain a balance between pro-inflammatory and anti-inflammatory processes at this level. Disturbing the immune homeostasis causes inflammation and allergic skin reaction. Psoriasis and atopic dermatitis are two inflammatory diseases of the skin, characterized by perturbation of the mechanisms of skin barrier formation. The immune system of the skin is also involved in the pathophysiology of vitiligo and pemphigus. The aim of this review is to offer a brief presentation of the inflammatory and immunological processes that occur in the skin.

References

Nov 1, 1992·The Journal of Dermatology·M Manabe, W M O'Guin
Jun 1, 1987·International Journal of Dermatology·W Westerhof, K P Dingemans
Oct 1, 1986·Journal of Cutaneous Pathology·W Westerhof, K P Dingemans
Aug 1, 1973·The Journal of Investigative Dermatology·K Fukuyama, W L Epstein
Jun 16, 2000·The Journal of Allergy and Clinical Immunology·R L OchsE M Tan
Aug 10, 2001·The Journal of Allergy and Clinical Immunology·S H ChoD Y Leung
Oct 11, 2002·The New England Journal of Medicine·Peck Y OngDonald Y M Leung
Dec 5, 2002·The Journal of Allergy and Clinical Immunology·Richard L GalloMohamed Zaiou
Jan 18, 2003·Lancet·Donald Y M Leung, Thomas Bieber
Mar 8, 2003·Pigment Cell Research·Katia OngenaeJean-Marie Naeyaert
May 20, 2003·Pigment Cell Research·Asem AlkhateebRichard A Spritz
Aug 21, 2003·American Journal of Clinical Dermatology·Jann Lübbe
Dec 6, 2003·The Journal of Allergy and Clinical Immunology·Jonathan M Spergel, Amy S Paller
Jul 10, 2004·Journal of the American Academy of Dermatology·Pearl E GrimesAllan Metzger
Jul 13, 2004·Clinical and Experimental Dermatology·A B De Sica, S Wakelin
Oct 13, 2006·JAMA : the Journal of the American Medical Association·Joel M GelfandAndrea B Troxel
Jul 31, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·Liana Manolache, Vasile Benea
May 31, 2008·Cell·Shimon SakaguchiMasahiro Ono
Nov 22, 2008·Journal of the American Academy of Dermatology·Pinar Y BasakVahide B Akkaya
Dec 2, 2008·Experimental Dermatology·Ehrhardt ProkschJens-Michael Jensen
Jan 9, 2009·The New England Journal of Medicine·Alain Taïeb, Mauro Picardo
Sep 8, 2010·Archives of Dermatological Research·Masae TakahashiTadashi Tezuka
Sep 14, 2010·Journal of Dermatological Science·Manabu Fujimoto
Dec 8, 2010·Immunologic Research·Makoto Inoue, Mari L Shinohara
Dec 17, 2010·Experimental Dermatology·E Helen KempAnthony P Weetman
Mar 11, 2011·The Journal of Allergy and Clinical Immunology·Emma Guttman-YasskyJames G Krueger
Jan 10, 2012·Annual Review of Immunology·Claudia Mauri, Anneleen Bosma
Jun 26, 2012·Nature Reviews. Immunology·Richard L Gallo, Lora V Hooper
Sep 28, 2012·The Journal of Investigative Dermatology·Rosa ParisiUNKNOWN Identification and Management of Psoriasis and Associated ComorbidiTy (IMPACT) project team
Oct 24, 2012·Experimental Dermatology·Jürgen HarderRegine Gläser
Mar 28, 2013·International Journal of Molecular Sciences·Kai H HänelJens Malte Baron
May 18, 2013·Nature Reviews. Immunology·Shimon SakaguchiHerman Waldmann
Jan 17, 2014·Science Translational Medicine·Christoph SchlapbachRachael A Clark
Feb 4, 2014·The Journal of Investigative Dermatology·Juan LiuAnthony A Gaspari
Jun 6, 2014·Journal of Immunology Research·A Batycka-BaranJ C Szepietowski
Jun 7, 2014·Mediators of Inflammation·Constantin CăruntuEugen Mandache
Jul 19, 2014·Biomarkers in Medicine·Constantin CaruntuMonica Neagu
Jul 22, 2014·The Journal of Investigative Dermatology·Ellen WitteRobert Sabat
Apr 8, 2015·Nature Reviews. Immunology·Mark H KaplanMatthew R Olson

❮ Previous
Next ❯

Citations

Jul 3, 2021·Biomolecules·Marija PetkovicHåvard Jenssen
Jan 25, 2022·Experimental and Therapeutic Medicine·Daciana Elena BranisteanuMihaela Paula Toader
Jan 25, 2022·Experimental and Therapeutic Medicine·Daciana Elena BranisteanuElena Andrese Porumb

❮ Previous
Next ❯

Related Concepts

Related Feeds

Atopic Dermatitis

Atopic dermatitis is a chronic inflammatory genetically determined disease of the skin marked by increased ability to form reagin (IgE), with increased susceptibility to allergic rhinitis and asthma, and hereditary disposition to a lowered threshold for pruritus. Discover the latest research on atopic dermatitis here.

Related Papers

Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række
Jens Roar Bjerke
Allergy and Asthma Proceedings
E N Charlesworth
© 2022 Meta ULC. All rights reserved