Skin allograft rejection in CD28-deficient mice

Transplantation
K KawaiP S Ohashi

Abstract

Costimulatory interactions between CD28 and the B7 family have been shown to augment T cell responses in general. To further assess the importance of the costimulatory signals generated through CD28, the allogeneic response was examined in CD28-deficient mice. T cells from CD28-deficient mice showed reduced proliferation and cytokine production in response to allogeneic stimulator cells in vitro. However, CD28-deficient T cells developed cytotoxic activity against allogeneic target cells in vitro and efficiently rejected skin allografts in vivo. These results suggest that the costimulatory signals through CD28 are not essential for the induction of alloreactive effector functions in vitro and in vivo.

References

Oct 1, 1992·The Journal of Experimental Medicine·C P LarsenR P Lowry
Nov 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·L A TurkaD Gordon
Sep 1, 1991·The Journal of Experimental Medicine·P S LinsleyJ A Ledbetter
Jun 15, 1990·Science·R H Schwartz
Jan 1, 1983·Annual Review of Immunology·K J LaffertyH S Warren
Mar 1, 1980·Transplantation·W C DavisR W Melvold
Dec 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·D J LenschowJ A Bluestone
Jul 1, 1994·Immunology Today·C H JuneC B Thompson
Sep 1, 1994·Immunity·J M GreenC B Thompson
Jan 31, 1995·Proceedings of the National Academy of Sciences of the United States of America·J G GribbenG S Gray
Aug 1, 1994·Immunity·T L WalunasJ A Bluestone
Jun 27, 1994·Transplantation·T C PearsonC P Larsen
Jan 1, 1993·Annual Review of Immunology·P S Linsley, J A Ledbetter

❮ Previous
Next ❯

Citations

Aug 6, 1998·European Journal of Immunology·L Tuosto, O Acuto
Feb 1, 1997·Immunologic Research·K G HeroldJ A Bluestone
Aug 29, 1998·Clinical Biochemistry·P F Halloran, S Prommool
Jun 22, 1999·Current Opinion in Immunology·T H Watts, M A DeBenedette
Oct 2, 2001·Critical Reviews in Oncology/hematology·P M McLaughlinL F de Leij
Oct 13, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·K Tamada, L Chen
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Ingrid C RulifsonJeffrey A Bluestone
May 20, 2003·Immunology and Cell Biology·Dass S VinayByoung S Kwon
Jun 10, 1998·The Journal of Experimental Medicine·K SaoulliT H Watts
Jul 7, 1998·The Journal of Experimental Medicine·F FallarinoT F Gajewski
Jul 28, 2010·The Journal of Experimental Medicine·Elizabeth D ThompsonVictor H Engelhard
Apr 15, 1997·Transplantation·D E SpeiserP S Ohashi
May 27, 1997·Transplantation·T C PearsonC P Larsen
Nov 7, 2012·Transplantation·Gillian KinnearKathryn J Wood
Oct 1, 1996·Immunological Reviews·W HolterW Knapp
Oct 1, 1996·Immunological Reviews·A I Sperling, J A Bluestone
Oct 6, 1997·The Journal of Clinical Investigation·T D BatiukP F Halloran
Jul 2, 1998·Clinical and Experimental Immunology·F A ArosaD N Posnett
Aug 1, 1997·European Journal of Immunology·T WenG Klein
Feb 1, 2005·European Journal of Immunology·Liqing WangWayne W Hancock
Jul 30, 2008·Transplant International : Official Journal of the European Society for Organ Transplantation·Maria-Luisa del RioJose-Ignacio Rodriguez-Barbosa
Aug 15, 2006·Immunological Reviews·David M Sansom, Lucy S K Walker
Apr 6, 2005·Transplantation Proceedings·G DindeleganM Olausson
Dec 18, 2013·Expert Opinion on Therapeutic Targets·Melissa Y YeungMohamed H Sayegh
Apr 30, 2002·International Immunology·Jun DengShoshana Levy
May 26, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·F SebilleJ P Soulillou
Aug 24, 1999·Immunology and Cell Biology·N L Harris, F Ronchese
Aug 16, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·David H GardnerDavid M Sansom
Dec 23, 1998·European Journal of Immunology·M C CookB Fazekas de St Groth

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.