Skin angiosarcoma arising in an irradiated breast: case-report and literature review

Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]
Fausto CatenaMario Taffurelli

Abstract

Angiosarcoma (AS) is a rare, invasive malignancy originating from endothelial cells caused by many different clinical situations. AS following radiotherapy for breast cancer after conservative surgery is a rare but well-known association. The aim of this article is to describe a case of AS after breast conserving surgery and to review the literature to date. We report the case of an 84-year-old woman who developed AS four years after she was subjected to quadrantectomy for invasive ductal cancer, followed by 30 tangent field radiotherapy sessions. She presented with a one-month history or red papular skin eruptions on the operated breast. Skin lesions were submitted for biopsy, and they were positive for AS. The patients was subjected to surgical excision of the remaining breast including all AS lesions. She is alive with no evidence of disease after 10 months follow-up. Post-radiotherapy AS is rare neoplasm, but it should be considered in the case of patients with red lesions after breast conserving surgery and adjuvant radiotherapy.

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Citations

Jul 8, 2009·American Journal of Clinical Oncology·Tithi BiswasMarilyn Ling
Mar 26, 2009·The American Journal of Dermatopathology·Rossitza LazovaAleksandar Godic
Jan 24, 2012·AJR. American Journal of Roentgenology·Thanissara ChansakulPriscilla J Slanetz
Jun 2, 2011·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·T PencavelA J Hayes
Jun 19, 2007·Journal of the American Academy of Dermatology·Ingerlisa W MattochSabine Kohler
Feb 2, 2010·Journal of Surgical Oncology·Jeffrey S ScowJudy C Boughey
Apr 16, 2014·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·A L DeplaG van Tienhoven

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