PMID: 9171763May 1, 1997Paper

Skin appendage involvement in anal intraepithelial neoplasia

The British Journal of Surgery
P SkinnerK Rogers

Abstract

High-grade anal intraepithelial neoplasia (AIN III) may be premalignant. Surgical excision of large areas of anal epithelium carries significant morbidity. Ablation treatments may carry less morbidity; however, the depth of ablation is uncertain and failure to ablate dysplasia in hair shafts and other skin appendages may lead to early recurrence. This study assesses morphometric aspects of skin appendages in perianal skin and anal canal mucosa in tissues from 30 patients with AIN III. Both normal and dysplastic epithelium was assessed in each patient. The depth to which AIN III involved skin appendages was measured using computerized image analysis. Both the perianal epidermis and anal canal mucosa affected by AIN III were significantly thicker than normal. Nineteen of 30 patients with AIN III had skin appendage involvement. Some 57 per cent of hair follicles (79 of 138), 16 per cent of sebaceous glands (11 of 69) and 25 per cent of sweat glands (24 of 96) observed beneath an abnormal epithelium had evidence of AIN. The median depth of AIN involvement of the hair follicle was 1.14 (range 0.44-1.67) mm, sebaceous glands 1.44 (range 0.96-1.90) mm, and sweat glands 0.94 (range 0.50-2.20) mm. These figures do not take into account ...Continue Reading

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Citations

Jul 20, 1999·Diseases of the Colon and Rectum·R K ClearyR M Lampman
May 2, 2000·Diseases of the Colon and Rectum·D J BrowseJ Nevin
Nov 12, 2005·Diseases of the Colon and Rectum·Bikash Devaraj, Bard C Cosman
Dec 3, 1999·The British Journal of Surgery·J H Scholefield
Feb 2, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J H ScholefieldA Radcliffe
Feb 26, 2010·Journal of Medical Case Reports·Filip TroickiAlbert Denittis
Nov 28, 2015·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Stefan EsserUlrike Wieland
Nov 13, 2007·Gastroenterology Clinics of North America·Neil A Shepherd
Jan 7, 2011·Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG·Wolfgang HartschuhAlex Furtwängler
Dec 30, 2011·The Neuroradiology Journal·S Shi, Y Zhao
Mar 1, 2005·The British Journal of Surgery·F Abbasakoor, P B Boulos
Jul 27, 2005·The British Journal of Surgery·J H ScholefieldN F S Watson

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