Abstract
We report an elderly patient who presented with a single cutaneous nodule of primary cutaneous Hodgkin's disease (PCHD). Reed-Sternberg cells, expressing CD30 and CD15, but not leukocyte common antigen (CD45RB), were identified in the neoplastic cells. Southern blot analysis failed to detect T-cell receptor or immunoglobulin gene rearrangement. A work-up for systemic disease at the time of presentation was negative, supporting the diagnosis of PCHD. Nevertheless, 1 year later, the disease course was complicated by the development of nodal HD and nonHodgkin's lymphoma (NHL). This case report supports the existence of this rare, but distinct, cutaneous tumor.
References
Jan 1, 1992·Virchows Archiv. A, Pathological Anatomy and Histopathology·A CarboneR Volpe
Sep 1, 1992·The American Journal of Surgical Pathology·H MomoseL M Weiss
Apr 23, 1992·The New England Journal of Medicine·T H DavisM E Kadin
May 1, 1992·Cancer·L B TravisE S Jaffe
Mar 1, 1992·Hematological Oncology·D TassiesC Rozman
Apr 1, 1990·Histopathology·G Pallesen
May 1, 1990·Journal of the American Academy of Dermatology·T G HayesM A Zubler
Jan 1, 1988·The American Journal of Surgical Pathology·S M ChittalG Delsol
Sep 1, 1987·The Journal of Pathology·C A AngelI Lauder
Nov 1, 1970·Cancer·D L BenninghoffM R Camiel
Nov 24, 1983·The New England Journal of Medicine·R A WarnkeD Y Mason
Jan 15, 1980·Cancer·J L Smith, J J Butler
Oct 1, 1995·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·K B Michels
Feb 1, 1994·The American Journal of Dermatopathology·N SioutosM E Kadin
Jan 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·E S JaffeL J Medeiros
Jun 1, 1995·Leukemia & Lymphoma·S J Gibbs, J S Tobias
Jun 1, 1996·Journal of Clinical Pathology·P BroussetG Delsol
Apr 10, 1997·The New England Journal of Medicine·P J Barnes, M Karin
May 1, 1948·The British Journal of Dermatology and Syphilis·L VAN DER MEIREN
Citations
Jun 10, 2004·The Journal of Dermatology·Suna ErkiliçCelalettin Camci
Jul 11, 2012·Current Hematologic Malignancy Reports·Nicholas A Barber, Philip J Bierman
Aug 28, 2003·Journal of the European Academy of Dermatology and Venereology : JEADV·V Stadie, W C H Marsch
Apr 14, 2020·Case Reports in Hematology·Nicole YunParameswaran Venugopal
Mar 31, 1999·The Australasian Journal of Dermatology·J A Pagliaro, S I White
Jun 17, 2006·Cancer Investigation·Vassilios PerifanisVassilia Garipidou
Oct 3, 2006·The American Journal of Dermatopathology·Dmitry V KazakovWerner Kempf
Sep 25, 2009·Journal of Cutaneous Pathology·Ibrahim KhalifehKlaus Sellheyer
Mar 10, 2016·The American Journal of Dermatopathology·Giang HuongCynthia M Magro
Jan 26, 2011·Journal of Cutaneous Pathology·Begoña VieitesFrancisco Carvajo
Jul 12, 2014·The American Journal of Dermatopathology·Mar Llamas-VelascoAmaro García-Diez
Sep 23, 2009·The American Journal of Dermatopathology·Keiji TaneseSyunichi Miyakawa
Nov 21, 2007·Dermatologic Clinics·Gabriela Rolz-Cruz, Caroline C Kim