Skin-autofluorescence, a measure of tissue advanced glycation end-products (AGEs), is related to diastolic function in dialysis patients

Journal of Cardiac Failure
Jasper W L HartogDirk J Van Veldhuisen

Abstract

Diastolic dysfunction is a frequent cause of heart failure, particularly in dialysis patients. Advanced glycation end-products (AGEs) are increased in dialysis patients and are suggested to play a role in the development of diastolic dysfunction. The aim of our study was to assess whether AGE accumulation in dialysis patients is related to the presence of diastolic dysfunction. Data were analyzed from 43 dialysis patients, age 58 +/- 15 years, of whom 65% were male. Diastolic function was assessed using tissue velocity imaging (TVI) on echocardiography. Tissue AGE accumulation was measured using a validated skin-autofluorescence (skin-AF) reader. Plasma N(epsilon)-(carboxymethyl)lysine (CML) and N(epsilon)-(carboxyethyl)lysine (CEL) were measured by stable-isotope-dilution tandem mass spectrometry. Plasma pentosidine was measured by high-performance liquid chromatography. Skin-AF correlated with mean E' (r = -0.51, P < .001), E/A ratio (r = -0.39, P = .014), and E/E' (r = 0.38, P = .019). Plasma AGEs were not significantly associated with diastolic function. Multivariable linear regression analysis revealed that 54% of the variance of average E' was explained by age (P = .007), dialysis type (P = 0.016), and skin-AF (P = .013)....Continue Reading

References

Jan 1, 1996·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·L J Striker, G E Striker
Mar 8, 2000·Proceedings of the National Academy of Sciences of the United States of America·M AsifT J Regan
Feb 7, 2001·Proceedings of the National Academy of Sciences of the United States of America·P V VaitkeviciusE G Lakatta
Oct 24, 2002·Journal of Molecular and Cellular Cardiology·Ralica PetrovaHiroshi Yamamoto
Apr 16, 2003·The American Journal of the Medical Sciences·Martin A Alpert
May 29, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Yuko IzuharaCharles van Ypersele de Strihou
Jul 23, 2005·Annals of the New York Academy of Sciences·Jasper W L HartogAndries J Smit
Nov 11, 2005·Journal of the American Society of Nephrology : JASN·Robbert MeerwaldtAndries J Smit
Jul 21, 2006·The New England Journal of Medicine·Theophilus E OwanMargaret M Redfield
Jul 21, 2006·The New England Journal of Medicine·R Sacha BhatiaPeter P Liu
Jul 21, 2006·The New England Journal of Medicine·Gerard P Aurigemma
Dec 1, 2006·Nephron. Clinical Practice·Giovambattista VirgaVittorio Rossi
Feb 13, 2007·Journal of the American College of Cardiology·Hans PerssonUNKNOWN Investigators of the CHARM Echocardiographic Substudy-CHARMES
Nov 8, 2007·European Heart Journal·Jasper W L HartogDirk J van Veldhuisen
Nov 21, 2007·European Journal of Heart Failure·Jasper W L HartogDirk J van Veldhuisen

❮ Previous
Next ❯

Citations

Dec 29, 2010·European Journal of Applied Physiology·Haruki MommaRyoichi Nagatomi
Sep 15, 2012·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Irena MakulskaDanuta Zwolińska
Nov 27, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Esther G GerritsHenk J G Bilo
Sep 17, 2010·Current Opinion in Nephrology and Hypertension·Andries J Smit, Esther G Gerrits
Jul 20, 2012·Nephron Extra·Esther G GerritsHenk J G Bilo
Sep 3, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Natasha J McIntyreMaarten W Taal
Nov 19, 2013·International Urology and Nephrology·Fabrice Mac-WayMohsen Agharazii
Jan 25, 2011·Heart Failure Reviews·Suzan WillemsenAdriaan A Voors
May 14, 2014·Experimental Gerontology·Britt HofmannAndreas Simm
Apr 4, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Solmaz AssaCasper F M Franssen
Feb 15, 2011·Medicina clínica·Sergio Raposeiras-RoubínJosé R González-Juanatey
Nov 21, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Irena MakulskaDanuta Zwolińska
May 18, 2016·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Pauline Bc LinssenCoen DA Stehouwer
Oct 23, 2010·Multiple Sclerosis : Clinical and Laboratory Research·Zohara SternbergFrederick Munschauer
Oct 18, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Yasuharu TabaraUNKNOWN Nagahama Study Group
May 31, 2014·Clinical Journal of the American Society of Nephrology : CJASN·Simon D S FraserMaarten W Taal
Aug 2, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Sho-Ichi Yamagishi
Apr 25, 2013·Clinical Chemistry and Laboratory Medicine : CCLM·Stefan ArsovAndries J Smit
May 19, 2017·Clinical Science·Marie FrimatEric Boulanger
Oct 8, 2019·Current Opinion in Nephrology and Hypertension·Daniela Viramontes Hörner, Maarten W Taal
Nov 13, 2015·Medicine·Emília MácsaiIstván Kiss

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2022 Meta ULC. All rights reserved