Skin Autofluorescence Is Associated with Endothelial Dysfunction in Uremic Subjects on Hemodialysis

PloS One
Chun-Cheng WangChiz-Tzung Chang

Abstract

Elevated levels of advanced glycation end products (AGEs) within tissues may contribute to endothelial dysfunction, an early indicator of atherosclerosis. We aimed to investigate whether levels of skin AGEs could be a useful marker to predict endothelial dysfunction in uremic subjects on hemodialysis. One hundred and nineteen uremic patients on hemodialysis and 57 control subjects with moderate-to-high cardiovascular risk factors and without chronic kidney disease (CKD) were enrolled. We used ultrasound to measure flow-mediated vasodilation (FMD). An AGE reader measured skin autoflurorescence (AF). We then compared differences in FMD and skin AF values between the two groups. The uremic subjects had significantly higher levels of skin AF (3.47±0.76 AU vs. 2.21±0.45 arbitrary units; P<0.01) and significantly lower levels of FMD (4.79%±1.88% vs. 7.19%±2.17%; P<0.01) than the non-CKD subjects. After adjusting for all potential covariates, we found that skin AF level independently predicted FMD in both the hemodialysis and the non-CKD groups. In the hemodialysis group, skin AF ≥ 3.05 arbitrary units predicted abnormal FMD at a sensitivity of 87.9% and a specificity of 78.6% (P<0.01). Skin AF could be a useful marker to predict endo...Continue Reading

References

Feb 29, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·D S RajM Levi
Jun 9, 2000·Kidney International·M F WeissV M Monnier
Nov 9, 2000·British Journal of Clinical Pharmacology·O T Raitakari, D S Celermajer
Jun 13, 2001·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·T MiyataC van Ypersele de Strihou
Jun 26, 2002·Kidney International·Susanne B SchwedlerChristoph Wanner
Oct 10, 2002·Kidney International·Jonathan HimmelfarbRaymond M Hakim
May 23, 2003·Journal of the American Society of Nephrology : JASN·Mohammed E SulimanPeter Stenvinkel
Aug 5, 2003·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Noriyuki SakataSeikoh Horiuchi
Oct 3, 2003·Journal of the American College of Cardiology·Michael E WidlanskyJoseph A Vita
Feb 9, 2005·Life Sciences·B Sönmez Uydeş-DoğanOsman Ozdemir
Jul 23, 2005·Annals of the New York Academy of Sciences·Vincent M MonnierSaul Genuth
Jan 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Zoltán WagnerIstván Wittmann
May 8, 2009·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·D J MulderA J Smit
Oct 20, 2010·Amino Acids·Teruo MiyazawaRyoji Nagai
Feb 22, 2011·The International Journal of Cardiovascular Imaging·Marjon J NoordzijClark J Zeebregts
Jun 22, 2011·Kidney & Blood Pressure Research·Philippe BrunetStéphane Burtey
Sep 16, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·K TanakaT Watanabe
Jul 17, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Yumiko IwamotoYukihito Higashi
Nov 10, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Lisanne C de VosJoop D Lefrandt

❮ Previous
Next ❯

Citations

Oct 8, 2019·Current Opinion in Nephrology and Hypertension·Daniela Viramontes Hörner, Maarten W Taal
Jul 15, 2020·International Urology and Nephrology·Seshadri Reddy VarikasuvuBalachandar Thangappazham

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy

Related Concepts

Related Feeds

Atrial Fibrillation

Atrial fibrillation is a common arrhythmia that is associated with substantial morbidity and mortality, particularly due to stroke and thromboembolism. Here is the latest research.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Atrial Filbrillation

Atrial fibrillation refers to the abnormal heart rhythm characterized by rapid and irregular beating of the atria. Here is the latest research.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.

Atherosclerosis Disease Progression

Atherosclerosis is the buildup of plaque on artery walls, causing stenosis which can eventually lead to clinically apparent cardiovascular disease. Find the latest research on atherosclerosis disease progression here.