Skin bacterial transplant in atopic dermatitis: Knowns, unknowns and emerging trends

Journal of Dermatological Science
Aleksi J HendricksVivian Y Shi

Abstract

Dysbiosis is a key pathogenic factor in the cycle of skin barrier impairment and inflammation in atopic dermatitis (AD). Skin microbial composition in AD is characterized by increased presence of Staphylococcus aureus (S. aureus) and decrease in microbial diversity and commensal bacterial species. Attenuation of S. aureus-driven inflammation aids in breaking the itch-scratch cycle via modulation of the cutaneous immune response. Skin bacterial transplant (SBT), a form of bacteriotherapy, is an intriguing treatment modality for restoration of a healthy skin microbiome in AD patients. Studies on the effects of topically-applied bacterial products, probiotics and SBT have yielded promising results in animal models and human studies of AD. This review discusses the rationale and evidence for SBT in AD and outlines future investigative directions for the clinical application of microbiome restoration in dermatology.

Citations

Nov 7, 2019·Experimental Dermatology·Takashi Hashimoto, Gil Yosipovitch
Nov 20, 2019·International Journal of Cosmetic Science·R SfrisoR Campiche
Mar 27, 2020·Dermatitis : Contact, Atopic, Occupational, Drug·Jonwei HwangVivian Y Shi
Aug 18, 2020·Virulence·Hala O EltwisyMohamed A El-Mokhtar
Jul 16, 2020·Microorganisms·Veronica MoskoviczBoaz Mizrahi
Dec 20, 2020·Dermatology and Therapy·Katlein França
Jan 29, 2021·Frontiers in Microbiology·Patrycja OgonowskaJoanna Nakonieczna
Feb 9, 2020·Annales de dermatologie et de vénéréologie·M Bagot

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