Skin biopsy and I-123 MIBG scintigraphy findings in idiopathic Parkinson's disease and parkinsonism: a comparative study

Movement Disorders : Official Journal of the Movement Disorder Society
Maria Pia GiannoccaroRocco Liguori

Abstract

(123) I-meta-iodobenzylguanidine ((123) I-MIBG) myocardial scintigraphy is considered reliable in differentiating idiopathic Parkinson's disease (IPD) from other parkinsonisms, but it is biased by pharmacological treatments. Skin biopsy is not influenced by therapy and has disclosed skin denervation in IPD. Our aims were to compare (123) I-MIBG scintigraphy and skin biopsy findings in IPD and parkinsonisms to (1) verify whether myocardial and skin denervations are linked; (2) explore the simultaneous extent of the autonomic dysfunction. We studied 22 IPD and 11 parkinsonism patients by means of (123) I-MIBG scintigraphy and skin biopsies. In the IPD group, both (123) I-MIBG scintigraphy and skin biopsy results were abnormal in 91% of patients, showing concordance in 82% of cases. In parkinsonisms, results of both tests were normal in all patients. (1) Skin biopsy and (123) I-MIBG scintigraphy provide comparable results; (2) in IPD, autonomic dysfunctions are often simultaneously widespread at cardiac and skin branches. © 2015 International Parkinson and Movement Disorder Society.

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Citations

Jul 16, 2015·Movement Disorders : Official Journal of the Movement Disorder Society·Kathrin DopplerClaudia Sommer
Jan 11, 2017·Journal of Neuropathology and Experimental Neurology·John M LeeThomas G Beach
Aug 1, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·David S Goldstein, William P Cheshire
Nov 23, 2017·Clinical Science·Ling GuoSusan J Corcoran
Jan 17, 2020·Muscle & Nerve·Majid Ghasemi, Yusuf A Rajabally
Jul 14, 2020·Expert Review of Neurotherapeutics·Grazia DevigiliGiuseppe Lauria
Nov 28, 2018·Annals of Clinical and Translational Neurology·Giorgia MelliAlain Kaelin-Lang
Dec 19, 2020·Journal of Neuromuscular Diseases·Lisette R M RaasingJan C Grutters
May 18, 2021·Frontiers in Neuroscience·Chengxiao MaMaohong Cao

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