Skin bleeding time for the evaluation of uremic platelet dysfunction and effect of dialysis

Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Yasemin Usul SoyoralReha Erkoc

Abstract

In patients with chronic kidney disease (CKD) predisposition to bleeding is frequently seen due to disturbances in platelet adhesion and aggregation. Various tests have been utilized to evaluate the disturbance of hemostasis in end-stage renal disease patients. In this trial; we evaluated skin bleeding time in patients admitted to our hospital with uremic symptoms and having hemodialysis (HD) for the first time. We also examined the effects of HD and uremia on this test and investigated its effectiveness in predicting the hemorrhagic complications before implementation of invasive procedures in uremic patients. Twenty nine patients (13 men,16 women; mean age 59.7 ± 18.1) with CKD who presented with symptoms of uremia and treated with HD for the first time were enrolled in this trial. The skin bleeding time were measured before initiation of first hemodialysis and after the second hemodialysis session. The skin bleeding time after the second dialysis was significantly shorter when compared to pre-dialysis values (p < 0.05). Correlation analysis between the skin bleeding time and urea, creatinine, hemoglobin, platelet, and bicarbonate showed no correlation. Skin bleeding time could reveal the uremic platelet dysfunction and benef...Continue Reading

References

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Aug 9, 2006·Seminars in Dialysis·Dinkar Kaw, Deepak Malhotra

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Citations

Oct 18, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jens LutzKlaus Thürmel
Jul 31, 2013·International Journal of Laboratory Hematology·C Tantanate, P Tientadakul
Nov 7, 2017·Transplant International : Official Journal of the European Society for Organ Transplantation·Gerhardus J A J M KuiperYvonne M C Henskens

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