Skin cancer in organ transplant recipients: dynamics in the incidence and clinical predictors for the first and subsequent post-transplant non-melanoma skin cancer

Journal of the European Academy of Dermatology and Venereology : JEADV
J HartmannA S Lonsdorf

Abstract

Risk factors for primary non-melanoma skin cancer (NMSC) in organ transplant recipients (OTR) have been well described. Data for subsequent NMSC and dynamics in their occurrence in OTR are limited. To study long-term risks of primary and subsequent NMSC and associated risk factors in OTR. A retrospective single-centre cohort study analysing medical records from a dermato-oncological specialty clinic. Of 464 OTR 110 (23.7%) developed at least one, 73 (15.7%) two and 51 (11%) three NMSC during a median follow-up of 9.6 years. Cumulative incidences at 5, 10 and 15 years were 14.7%, 23.5% and 34.5% for the first and 75.8%, 86.5% and 93.3% for the second. Median time-to-diagnosis declined from 22 years (95% CI 19-25) to 2 years (1-3) and about 1 year (0-2) for the first, second and third NMSC. Risk for subsequent NMSC only partially related to risk factors for the primary NMSC. Histologic type of the first NMSC predicted subtype and time-to-diagnosis of the subsequent NMSC. A first post-transplant NMSC, particularly a SCC, confers a high risk for subsequent NMSC arising with accelerated dynamics. Risk-adapted dermato-oncologic surveillance is advisable for all OTR.

References

Jan 28, 1999·Journal of the American Academy of Dermatology·C S OngP M Spratt
Jun 30, 2000·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·H M RamsayP N Harden
Jun 22, 2002·Journal of the American Academy of Dermatology·Daniel Berg, Clark C Otley
Mar 4, 2003·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Robert P CarrollPaul N Harden
Apr 25, 2003·The New England Journal of Medicine·Sylvie EuvrardAlain Claudy
Apr 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Leslie J ChristensonClark C Otley
Apr 6, 2004·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Thomas StaskoUNKNOWN European Skin Care in Organ Transplant Patients Network
Oct 16, 2004·The Journal of Investigative Dermatology·John A Carucci
Feb 1, 2006·The British Journal of Dermatology·F J MoloneyG M Murphy
Mar 3, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·P J VilleneuveY Mao
Oct 6, 2007·The British Journal of Dermatology·C C OtleyUNKNOWN Reduction of Immunosuppression Task Force of the International Transplant Skin Cancer Collaborative
Dec 12, 2007·The British Journal of Dermatology·W L Ho, G M Murphy
Sep 11, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C UlrichS Euvrard
Sep 29, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Katarzyna A MackenzieMargaret J Currie
Oct 23, 2009·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
Dec 23, 2009·Archives of Dermatology·Jerry D BrewerClark C Otley
Feb 24, 2010·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·A S LonsdorfC Ulrich
Jun 30, 2011·The British Journal of Dermatology·S C FlohilT Nijsten
Jul 27, 2012·The New England Journal of Medicine·Sylvie EuvrardUNKNOWN TUMORAPA Study Group
Aug 14, 2012·International Journal of Cancer. Journal International Du Cancer·Britta KrynitzKarin E Smedby
Oct 18, 2012·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·C A HarwoodC M Proby
Oct 31, 2012·Journal of the American Academy of Dermatology·Ravinder GogiaSarah T Arron
Dec 3, 2014·Journal of the American Academy of Dermatology·Shadi RashtakClark C Otley
Sep 13, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·R J T van der LeestE de Vries
Jan 9, 2018·Journal of the American Academy of Dermatology·Pamela Funk-DebledsJérôme Dumortier
Apr 25, 2018·American Journal of Clinical Dermatology·Matthew D HowardAlvin H Chong

❮ Previous
Next ❯

Citations

Nov 11, 2020·Journal of Clinical Medicine·Kerstin HerzerFrank Tacke
Dec 29, 2020·Clinical Case Reports·Soumaya GaraFaten Zeglaoui

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Basal Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons
A FrancisG Wong
© 2022 Meta ULC. All rights reserved