Skin collagen advanced glycation endproducts (AGEs) and the long-term progression of sub-clinical cardiovascular disease in type 1 diabetes

Cardiovascular Diabetology
Vincent M MonnierDCCT/EDIC Research Group

Abstract

We recently reported strong associations between eight skin collagen AGEs and two solubility markers from skin biopsies obtained at DCCT study closeout and the long-term progression of microvascular disease in EDIC, despite adjustment for mean glycemia. Herein we investigated the hypothesis that some of these AGEs (fluorescence to be reported elsewhere) correlate with long-term subclinical cardiovascular disease (CVD) measurements, i.e. coronary artery calcium score (CAC) at EDIC year 7-9 (n = 187), change of carotid intima-media thickness (IMT) from EDIC year 1 to year 6 and 12 (n = 127), and cardiac MRI outcomes at EDIC year 15-16 (n = 142). Skin collagen AGE measurements obtained from stored specimens were related to clinical data from the DCCT/EDIC using Spearman correlations and multivariable logistic regression analyses. Spearman correlations showed furosine (early glycation) was associated with future mean CAC (p < 0.05) and CAC >0 (p = 0.039), [corrected] but not with CAC score <100 vs. >100. Glucosepane and pentosidine crosslinks, methylglyoxal hydroimidazolones (MG-H1) and pepsin solubility (inversely) correlated with IMT change from year 1 to 6(all P < 0.05). Left ventricular (LV) mass (cMRI) correlated with MG-H1, a...Continue Reading

References

Nov 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R H NagarajV M Monnier
Jul 15, 1999·The International Journal of Biochemistry & Cell Biology·R G Paul, A J Bailey
Feb 10, 2000·The New England Journal of Medicine·UNKNOWN Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Research GroupDavid M Nathan
Jun 6, 2003·The New England Journal of Medicine·David M NathanUNKNOWN Epidemiology of Diabetes Interventions and Complications Research Group
Jan 29, 2005·The Journal of Biological Chemistry·David R SellVincent M Monnier
Jan 19, 2007·The Journal of Biological Chemistry·Sandra A C ChongChristopher A McCulloch
Oct 6, 2009·Matrix Biology : Journal of the International Society for Matrix Biology·Sihem Sassi-GahaCarol M Artlett
Apr 29, 2010·Matrix Biology : Journal of the International Society for Matrix Biology·Amy YuenC A McCulloch
Sep 29, 2011·Circulation·Evrim B TurkbeyUNKNOWN DCCT/EDIC Research Group
Mar 30, 2012·Current Medicinal Chemistry·G J S Cooper
Nov 17, 2012·Journal of Diabetes and Its Complications·Vincent M MonnierUNKNOWN DCCT Research Group
Oct 19, 2013·Cardiovascular Diabetology·Marcelle G A van EupenCasper G Schalkwijk
Jan 21, 2014·Diabetes & Vascular Disease Research : Official Journal of the International Society of Diabetes and Vascular Disease·Kari Anne SveenKjetil Steine

❮ Previous
Next ❯

Citations

Sep 17, 2016·Medicinal Research Reviews·Paulo MatafomeRaquel Seiça
Aug 25, 2016·Journal of Diabetes·Sho-Ichi YamagishiTakanori Matsui
Nov 29, 2017·International Journal of Molecular Sciences·Alena SobolevaAndrej Frolov
Apr 13, 2018·Rejuvenation Research·Sho-Ichi Yamagishi, Takanori Matsui
Aug 2, 2019·Circulation Journal : Official Journal of the Japanese Circulation Society·Sho-Ichi Yamagishi
Feb 18, 2016·Cardiovascular Diabetology·Timothy J BradleyDavid Z I Cherney
Sep 3, 2016·Cardiovascular Diabetology·Fritz-Line Vélayoudom-CéphiseVincent Rigalleau
Nov 8, 2018·Annals of Vascular Diseases·Sho-Ichi Yamagishi, Takanori Matsui
Jul 31, 2019·International Journal of Molecular Sciences·Kristina AntonovaAndrej Frolov
Feb 23, 2020·Diabetes·Rachel G Miller, Trevor J Orchard
May 29, 2021·Biochemical and Biophysical Research Communications·Ko SugiuraYuki Ogasawara
Jul 3, 2021·International Journal of Molecular Sciences·Ivana Sirangelo, Clara Iannuzzi

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsy
biopsies

Software Mentioned

Medalist

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Cardiovascular Diseases: Risk Factors

Cardiovascular disease is a significant health concern. Risk factors include hypertension, obesity, dyslipidemia and smoking. Women who are postmenopausal are at an increased risk of heart disease. Here is the latest research for risk factors of cardiovascular disease.

Cardiovascular Disorder in Diabetes

Diabetes is associated with an increased risk of cardiovascular disorders and heart failure. Discover the latest research here.

Biomarkers for Cardiovascular Risk Assessment

Sensitive and accurate biomarkers used in cardiovascular risk prediction can potentially be used to manage the risk of cardiovascular disease. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here. Discover the latest research on Biomarkers for Cardiovascular Risk Assessment here.

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.

© 2021 Meta ULC. All rights reserved