Skin corrosivity potential of fatty acids: In vitro rat and human skin testing and QSAR studies

Toxicology in Vitro : an International Journal Published in Association with BIBRA
E WhittleM Chamberlain

Abstract

The corrosive potential of a series of fatty acids-propanoic acid (C3), butanoic acid (C4), hexanoic acid (C6), octanoic acid (C8), decanoic acid (C10) and dodecanoic acid (C12)-was investigated in the in vitro skin corrosivity test (IVSCT) using both rat skin and human skin. All the fatty acids with alkyl chain lengths up to and including C8 were found to be corrosive to rat skin. When human skin was used, the corrosive/non-corrosive threshold was shifted to around the C6 fatty acid. The results are discussed in the context of a QSAR for the corrosivity of organic acids, with the putative mechanism that corrosivity is a function of the ability of the chemical to permeate the skin together with its cytotoxicity, expressed in this case as acidity (pK(a)). This mechanistic interpretation is consistent with the known differences in barrier properties between rat and human skin.

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May 1, 1993·Toxicology in Vitro : an International Journal Published in Association with BIBRA·E Whittle, D A Basketter

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Citations

Apr 17, 2002·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·M K RobinsonJ H Fentem
Jun 1, 1997·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J N Lawrence
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Dec 5, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·George A Burdock, Ioana G Carabin
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Feb 14, 2021·International Journal of Pharmaceutics·Anthony LaiChristopher J H Porter

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