Skin decontamination of glyphosate from human skin in vitro

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
H ZhaiH I Maibach

Abstract

This study compared three model decontaminant solutions (tap water, isotonic saline, and hypertonic saline) for their ability to remove a model herbicide (glyphosate) from an in vitro human skin model. Human cadaver skin was dosed (approximately 375microg) of [14C]-glyphosate on 3cm2 per skin. After each exposure time (1, 3, and 30min post-dosing, respectively), the surface skin was washed three times (4ml per time) with each solution. After washing, the skin was stripped twice with tape discs. Lastly, the wash solutions, strippings, receptor fluid, and remainder of skin were liquid scintillation analyzer counted to determine the amount of glyphosate. There were no statistical differences among these groups at any time points. The total mass balance recovery at three time exposure points was between 94.8% and 102.4%. The wash off rates (glyphosate in wash solutions) at three different exposure times is 79-101.2%. Thus the three tested decontaminants possess similar effectiveness in removing glyphosate from skin. This in vitro model is not only economic and rapid, but also provides quantitative data that may aid screening for optimal decontaminants.

References

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Nov 25, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·H ZhaiH I Maibach

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Citations

May 27, 2010·International Archives of Occupational and Environmental Health·Jesper Bo Nielsen
May 8, 1999·Immunology·L T Van Den BroekeA Scheynius
Jan 14, 2010·Case Reports in Medicine·John N MakaryusDavid Slotwiner
Jun 26, 2014·Cutaneous and Ocular Toxicology·Barbara NouryHoward Maibach
Mar 21, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Kathrin DennerleinGintautas Korinth
Aug 2, 2012·Toxicology and Industrial Health·Heidi P ChanHoward I Maibach
Jan 10, 2018·Journal of Applied Toxicology : JAT·Yachao CaoHoward Maibach
May 30, 2021·Chemico-biological Interactions·Greta Camilla MagnanoFrancesca Larese Filon
Jul 27, 2021·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Chavy ChiangHoward Maibach

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