Skin deep: enhanced sleep depth by cutaneous temperature manipulation

Brain : a Journal of Neurology
Roy J E M RaymannEus J W Van Someren

Abstract

With ageing, an increasingly disturbed sleep is reported as a significant complaint affecting the health and well-being of many people. The available treatments for sleep disturbance have their limitations, so we have adopted a different approach to the improvement of sleep. Since in animal and human studies skin warming has been found to increase neuronal activity in brain areas that are critically involved in sleep regulation, we investigated whether subtle skin temperature manipulations could improve human sleep. By employing a thermosuit to control skin temperature during nocturnal sleep, we demonstrate that induction of a mere 0.4 degrees C increase in skin temperature, whilst not altering core temperature, suppresses nocturnal wakefulness (P<0.001) and shifts sleep to deeper stages (P<0.001) in young and, especially, in elderly healthy and insomniac participants. Elderly subjects showed such a pronounced sensitivity, that the induced 0.4 degrees C increase in skin temperature was sufficient to almost double the proportion of nocturnal slow wave sleep and to decrease the probability of early morning awakening from 0.58 to 0.04. Therefore, skin warming strongly improved the two most typical age-related sleep problems; a dec...Continue Reading

References

Feb 1, 1976·The American Journal of Physiology·M A BakerD G Mountjoy
Dec 1, 1990·Trends in Neurosciences·D McGinty, R Szymusiak
Feb 1, 1985·Electroencephalography and Clinical Neurophysiology·J A Horne, A J Reid
Dec 1, 1973·The American Journal of Physiology·J A Boulant, K E Bignall
May 15, 1984·Experientia·A MuzetV Candas
Feb 9, 1981·Brain Research·P A Doris, M A Baker
Apr 1, 1996·Journal of Geriatric Psychiatry and Neurology·C M DorseyA Satlin
Mar 1, 1996·Journal of Sleep Research·L C Lack, K Lushington
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·P Tikuisis, M B Ducharme
Jul 1, 1997·Applied Human Science : Journal of Physiological Anthropology·K OkamotoN Okudaira
Dec 22, 1998·Journal of Psychosomatic Research·Y SweereR J Schimsheimer
Jul 17, 1999·European Journal of Applied Physiology and Occupational Physiology·K KandaT Ohnaka
Sep 15, 1999·Nature·K KräuchiA Wirz-Justice
Sep 9, 2000·Journal of Physiological Anthropology and Applied Human Science·E J Sung, Y Tochihara
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·K Kräuchi, A Wirz-Justice
Mar 20, 2003·Behaviour Research and Therapy·K L LichsteinB W Riedel
Oct 22, 2003·Journal of Clinical Epidemiology·Jean Mundahl Engels, Paula Diehr
Jan 29, 2005·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Roy J E M RaymannEus J W Van Someren
Feb 3, 2005·Sleep·Jack D EdingerUNKNOWN American Academy of Sleep Medicine Work Group
Mar 29, 2005·Proceedings of the National Academy of Sciences of the United States of America·Gary F EganPeter T Fox
Jun 27, 2006·Physiology & Behavior·Wouter D van Marken LichtenbeltEus J W Van Someren
Jun 29, 2006·JAMA : the Journal of the American Medical Association·Børge SivertsenInger Hilde Nordhus
Jul 14, 2006·Menopause : the Journal of the North American Menopause Society·Robert R Freedman, Timothy A Roehrs
Aug 1, 2006·Progress in Brain Research·Eus J W Van Someren
Aug 12, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eus J W Van Someren
Oct 17, 2006·Sleep·Daniel J BuysseCharles M Morin
Apr 1, 1968·Journal of Religion and Health·V McCarthy

❮ Previous
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Citations

Dec 31, 2009·International Journal of Biometeorology·Kazue Okamoto-Mizuno, Kazuyo Tsuzuki
Aug 1, 2012·Current Hypertension Reports·Sogol Javaheri, Susan Redline
Sep 3, 2010·Proceedings of the National Academy of Sciences of the United States of America·Eus J W Van Someren
Dec 16, 2010·Nursing·Tina Weitzel, PICHE Group
Oct 27, 2011·Neuroreport·Azra PremjiAimee J Nelson
Jun 29, 2012·Journal of Physiological Anthropology·Kazue Okamoto-Mizuno, Koh Mizuno
Apr 12, 2013·PloS One·Antonio Martinez-NicolasJuan Antonio Madrid
Feb 14, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Giovanni PiantoniEus J W Van Someren
Jan 15, 2013·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Jennifer R RamautarEus J W Van Someren
Jul 26, 2012·Journal of Neural Transmission·Els I S MostEus J W Van Someren
Dec 23, 2014·Journal of Clinical Medicine·Patricia J MurphyDemitri Papolos
Nov 4, 2011·Pflügers Archiv : European journal of physiology·Nico RomeijnEus J W Van Someren
Feb 1, 2013·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Keith M StudholmeLawrence P Morin
Feb 7, 2016·Applied Ergonomics·Kazue Okamoto-MizunoKatsuko Niwano
Dec 19, 2012·Clinics in Dermatology·Madhulika A Gupta, Aditya K Gupta
Oct 21, 2015·Current Biology : CB·Gandhi YetishJerome M Siegel
May 26, 2009·Physiology & Behavior·Deependra KumarVelayudhan Mohan Kumar
Jul 8, 2008·Sleep Medicine Reviews·Leon C LackKurt Lushington
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Patrick M FullerMichael Lazarus
Oct 11, 2008·Journal of Sleep Research·Ellemarije AltenaEus J W Van Someren
Dec 7, 2011·The Journal of Clinical Hypertension·Robert D BrookRon Williams
Jan 1, 2014·The European Journal of Neuroscience·Éva Szentirmai, Levente Kapás
Apr 29, 2015·Journal of Sleep Research·Astrid van der HeideRolf Fronczek
Dec 18, 2013·Annals of the New York Academy of Sciences·Ellen FrankBrant P Hasler
May 27, 2016·Temperature : Multidisciplinary Biomedical Journal·Eus J W Van SomerenSophie van der Sluis
Aug 16, 2014·Sleep Medicine Reviews·Mounir ChennaouiDamien Léger
Nov 21, 2014·Aging Clinical and Experimental Research·Zeynel Abidin ÖztürkYalçın Kepekçi
May 12, 2016·Behavioral Sleep Medicine·Kazue Okamoto-MizunoShuichiro Shirakawa
May 20, 2016·Industrial Health·Cassie J HilditchSiobhan Banks
Jan 22, 2011·Journal of Biological Rhythms·Nico Romeijn, Eus J W Van Someren
Jul 28, 2017·Brain Injury : [BI]·Claude Touzet

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