Abstract
The mesenchymal stem cells (MSCs) are able to accumulate at the site of tissue damage. For this reason, they must transmigrate across the endothelium. In this study, we focused on skin-derived MSCs (S-MSCs), because the skin represents a useful stem cell source, and we analysed the VEGF released by S-MSCs, because it is known to promote endothelial cell proliferation and vascular permeability. Moreover, we evaluated the influence of S-MSC-conditioned medium on human aortic endothelial cell intracellular calcium concentration ([Ca(2+)](i)) and nitric oxide (NO) production, given their important role in endothelial permeability modulation. Our results suggest that human S-MSCs may interact with the endothelium via paracrine mechanisms, probably leading to an alteration of the endothelial barrier. Consequently, we could hypothesize that a therapeutic approach based on human skin-derived MSCs may have a positive effect on tissue repair.
References
May 1, 1992·The Journal of Cell Biology·C A ParkosJ L Madara
Jul 1, 1990·Diabetes·L MazzantiR De Pirro
Mar 1, 1993·The Journal of Cell Biology·A J HuangS C Silverstein
Feb 18, 1997·Circulation·R van der ZeeJ M Isner
Jan 31, 1998·The Journal of Clinical Investigation·A PapapetropoulosW C Sessa
Apr 2, 1999·Science·M F PittengerD R Marshak
Aug 16, 2001·The Anatomical Record·H E YoungA C Black
Sep 5, 2001·Nature Cell Biology·J G TomaF D Miller
Jan 24, 2004·Circulation Research·T KinnairdS E Epstein
Mar 17, 2004·Circulation·T KinnairdS E Epstein
Jul 10, 2004·Circulation Research·Mark F Pittenger, Bradley J Martin
Apr 28, 2005·Current Pharmaceutical Design·Donald G Phinney, Iryna Isakova
Jul 7, 2005·Tissue Engineering·Reinhard GruberGeorg Watzek
Apr 19, 2006·Journal of Cellular Biochemistry·Arnold I Caplan, James E Dennis
Jul 11, 2006·European Journal of Cell Biology·Annette SchmidtWilhelm Bloch
May 15, 2007·Endothelium : Journal of Endothelial Cell Research·Dennis LadageAnnette Schmidt
Jun 15, 2007·Molecular & Cellular Proteomics : MCP·Siu Kwan SzeSai-Kiang Lim
Nov 15, 2007·Cell Cycle·Donald G Phinney
Feb 6, 2008·Journal of Autoimmunity·Keiya OzawaAkihiro Kume
May 3, 2008·Journal of Tissue Engineering and Regenerative Medicine·Harumi KagiwadaHajime Ohgushi
May 9, 2008·Journal of Molecular and Cellular Cardiology·Caroline SteingenWilhelm Bloch
Jun 17, 2008·Acta histochemica·Monia OrcianiEleonora Salvolini
Sep 23, 2008·Experimental Dermatology·Alexander StoffDavid T Curiel
Jan 27, 2009·Journal of Cellular Physiology·Rosendo EstradaEugenia Wang
Citations
Dec 15, 2011·Cardiovascular Drugs and Therapy·Amalia ForteMarilena Cipollaro
May 25, 2012·Stem Cell Reviews and Reports·C FerrettiM Mattioli-Belmonte
Dec 23, 2015·Acta Biomaterialia·Yanyi XuJianjun Guan
Jun 5, 2012·Cancer Letters·Jorge S BurnsMassimo Dominici
May 9, 2013·International Journal of Cosmetic Science·C A BrohemM Lorencini
Oct 7, 2015·Frontiers in Physiology·Monica Mattioli-BelmonteMirella Falconi
Mar 1, 2014·Tissue Engineering. Part a·Concetta FerrettiMonica Mattioli-Belmonte
Nov 1, 2016·Pituitary·Monia OrcianiRoberto Di Primio
Sep 25, 2015·Stem Cells Translational Medicine·Qun LiPingjin Gao
Sep 18, 2016·The British Journal of Dermatology·M OrcianiR Di Primio
Aug 15, 2014·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J C ZhangW X Li
Jan 22, 2019·Experimental Dermatology·Ruifeng LiuKaiming Zhang
Oct 25, 2016·Experimental Dermatology·Anna CampanatiAnnamaria Offidani
Nov 8, 2018·Stem Cells International·Bo La HanCaigan Du
Jun 3, 2020·Cells·Hyun Ah OhSoyoun Um
Apr 11, 2021·Experimental Dermatology·Wenjuan ChangKaiming Zhang
Mar 22, 2021·Aging·Cihui YanXiubao Ren
Jul 1, 2021·Regenerative Medicine·Thomas KirwinBrian Wang