Skin-Derived Stem Cells for Wound Treatment Using Cultured Epidermal Autografts: Clinical Applications and Challenges

Stem Cells International
Inga BrockmannJohannes Boltze

Abstract

The human skin fulfills important barrier, sensory, and immune functions-all of which contribute significantly to health and organism integrity. Widespread skin damage requires immediate treatment and coverage because massive skin loss fosters the invasion of pathogens, causes critical fluid loss, and may ultimately lead to death. Since the skin is a highly immunocompetent organ, autologous transplants are the only viable approach to permanently close a widespread skin wound. Despite the development of tissue-saving autologous transplantation techniques such as mesh and Meek grafts, treatment options for extensive skin damage remain severely limited. Yet, the skin is also a rich source of stem and progenitor cells. These cells promote wound healing under physiological conditions and are potential sources for tissue engineering approaches aiming to augment transplantable tissue by generating cultured epidermal autografts (CEAs). Here, we review autologous tissue engineering strategies as well as transplantation products based on skin-derived stem cells. We further provide an overview of clinical trial activities in the field and discuss relevant translational and clinical challenges associated with the use of these products.

References

Aug 1, 1990·Journal of the American Academy of Dermatology·T J PhillipsB A Gilchrest
Jun 1, 1991·Burns : Journal of the International Society for Burn Injuries·V RonfardJ J Huart
Feb 1, 1991·Annals of Plastic Surgery·S J DeanW L Hickerson
Jan 1, 1990·The British Journal of Dermatology·R G TeepeB J Vermeer
Mar 1, 1990·The Journal of Surgical Research·M L CooperD H Frank
Apr 1, 1990·Plastic and Reconstructive Surgery·A L Moss
Jul 1, 1989·Plastic and Reconstructive Surgery·G G GallicoH Green
Oct 4, 1986·Lancet·J A ClarkeB A Gusterson
Sep 1, 1988·Annals of Surgery·D HeimbachG Warden
Oct 1, 1987·Plastic and Reconstructive Surgery·C B CuonoJ McGuire
Nov 1, 1986·Clinical and Experimental Dermatology·I M Leigh, P E Purkis
Jun 30, 1984·Lancet·A Wynn
Aug 16, 1984·The New England Journal of Medicine·G G GallicoH Green
Jan 13, 1995·Cell·P H JonesF M Watt
Jan 1, 1996·Annals of Surgery·T T NguyenD N Herndon
May 1, 1997·Burns : Journal of the International Society for Burn Injuries·J E Paddle-LedinekJ P Masterton
Sep 1, 1997·Pediatric Surgery International·M Meuli, M Raghunath
Aug 26, 1998·The Journal of Burn Care & Rehabilitation·H MatsumuraD M Heimbach
May 19, 2000·Annals of Surgery·J P BarretD N Herndon
Feb 28, 2001·Burns : Journal of the International Society for Burn Injuries·A M MunsterA Shalom
Aug 17, 2001·Tissue Engineering·N O OjehH A Navsaria
Sep 24, 2002·Nature Medicine·Susana Ortiz-UrdaPaul A Khavari
Nov 28, 2002·Nature Biotechnology·Aaron Bouchie
Jul 9, 2003·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Anne-Kathrin TauscheThomas Hunziker
Dec 31, 2003·Biomaterials·E MiddelkoopM M W Ulrich
Oct 1, 2004·Plastic and Reconstructive Surgery·Christoph TheopoldElof Eriksson
Dec 9, 2004·Human Gene Therapy·Yannick GacheGuerrino Meneguzzi
Jan 6, 2006·The Journal of Clinical Investigation·George Cotsarelis
Jan 6, 2006·The Journal of Clinical Investigation·Manabu OhyamaJonathan C Vogel
Feb 8, 2006·Plastic and Reconstructive Surgery·Christoph Theopold, Elof Eriksson

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies
biopsy

Clinical Trials Mentioned

NCT01263379

Software Mentioned

EpiDex

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Related Papers

Bulletin de l'Académie nationale de médecine
Jean-Jacques LatailladeLaurent Bargues
Transfusion clinique et biologique : journal de la Société française de transfusion sanguine
J-J LatailladeM Trouillas
Pathologie-biologie
Laurent BarguesJ-J Lataillade
© 2022 Meta ULC. All rights reserved