PMID: 9552752Apr 29, 1998Paper

Skin diseases associated with hepatitis C virus infection

Journal of the European Academy of Dermatology and Venereology : JEADV
S J Hadziyannis

Abstract

Hepatitis C virus (HCV) is a bloodborne agent transmitted by apparent and inapparent parenteral procedures representing a frequent cause of liver disease world-wide. Both acute and chronic HCV infection may affect the liver as well as various non-hepatic tissues. Numerous extrahepatic disorders have been recognised in association with HCV infection among which dermatological diseases occupy a central part. Cutaneous necrotising vasculitis, mixed cryoglobulinemia, porphyria cutanea tarda and lichen planus are the major skin diseases frequently associated with HCV infection, but other skin disorders, such as Adamantiadis-Behçet syndrome, erythema multiforme and nodosum, malacoplakia, urticaria and pruritus, may also be linked to hepatitis C. Further studies are necessary to establish or refute an aetiopathogenetic role of HCV in these conditions. Skin manifestations are also part of the clinical picture of other extrahepatic disorders associated with HCV infection, such as thyroid dysfunction and HCV-related thrombocytopenia. The response to interferon alpha (alpha-IFN) therapy in skin diseases is unpredictable with some patients ameliorating, others remaining stationary and others deteriorating.

Citations

Dec 11, 1999·Clinics in Dermatology·L E Millikan, T C Flynn
Jan 13, 2000·Clinics in Dermatology·L AtzoriP Biggio
Jun 1, 2001·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·L G Naimeh, B A Muller
Apr 16, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·M R BongiornoG Aricò
Oct 18, 2006·European Journal of Haematology·Simon PanzerMarkus Peck-Radosavljevic
Jul 11, 2006·Journal of Gastroenterology and Hepatology·Tarek M El-GhandourManal H El-Sayed
Sep 19, 2012·Clinical & Developmental Immunology·Takashi Himoto, Tsutomu Masaki
May 17, 2013·International Journal of Dermatology·Mona Halawani
Feb 7, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kiminori Kimura
Sep 11, 2004·Journal of Viral Hepatitis·G CampisiM D Mignogna
Dec 13, 2005·International Journal of Dermatology·Ahmad Abdelgawad NofalMagda Assaf
Sep 2, 2005·International Journal of Dermatology·Zahra RahnamaSaideh Farajzadeh
Jul 15, 2015·TheScientificWorldJournal·Alexander PazHanns de la Fuente-Mella

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