Skin innervation at different depths correlates with small fibre function but not with pain in neuropathic pain patients

European Journal of Pain : EJP
Marcus SchleyMartin Schmelz

Abstract

Neuropathy can lead not only to impaired function but also to sensory sensitization. We aimed to link reduced skin nerve fibre density in different levels to layer-specific functional impairment in neuropathic pain patients and tried to identify pain-specific functional and structural markers. In 12 healthy controls and 36 patients with neuropathic pain, we assessed clinical characteristics, thermal thresholds (quantitative sensory testing) and electrically induced pain and axon reflex erythema. At the most painful sites and at intra-individual control sites, skin biopsies were taken and innervation densities in the different skin layers were assessed. Moreover, neuronal calcitonin gene-related peptide staining was quantified. Perception of warm, cold and heat pain and nerve fibre density were reduced in the painful areas compared with the control sites and with healthy controls. Warm and cold detection thresholds correlated best with epidermal innervation density, whereas heat and cold pain thresholds and axon reflex flare correlated best with dermal innervation density. Clinical pain ratings correlated only with epidermal nerve fibre density (r = 0.38, p < 0.05) and better preserved cold detection thresholds (r = 0.39, p < 0....Continue Reading

References

Dec 29, 1998·Archives of Neurology·J C McArthurJ W Griffin
Apr 11, 2001·Neurology·V NovakJ R Mendell
May 7, 2004·Brain : a Journal of Neurology·Chia-Tung ShunSung-Tsang Hsieh
Sep 29, 2004·Diabetes Care·Heidrun H KrämerFrank Birklein
Jun 7, 2005·Muscle & Nerve·Kiesa Getz KellyMisha-Miroslav Backonja
Aug 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jeffrey S MogilPeter W Reeh
Mar 29, 2006·Diabetes Care·Lea SorensenDennis K Yue
Nov 3, 2007·Pain·Eske Kvanner AasvangHenrik Kehlet
Jan 31, 2008·The Journal of Pain : Official Journal of the American Pain Society·Anne Louise Oaklander
Jun 6, 2008·Brain : a Journal of Neurology·Grazia DevigiliGiuseppe Lauria
Jun 12, 2008·Diabetic Medicine : a Journal of the British Diabetic Association·E Vlckova-MoravcovaC Sommer
Apr 11, 2009·PLoS Medicine·Joachim ScholzClifford J Woolf
Jun 30, 2009·The Journal of Pain : Official Journal of the American Pain Society·Alla KhodorovaGary Strichartz
Dec 22, 2009·Journal of the Peripheral Nervous System : JPNS·Andreas BickelBarbara Namer
Mar 17, 2010·European Journal of Pain : EJP·Sa H LanderholmPer T Hansson
Mar 20, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·G CruccuR-D Treede
May 12, 2010·Pain·Karin Lottrup PetersenMichael C Rowbotham
Oct 15, 2010·The New England Journal of Medicine·Nancy E LaneMark T Brown
Apr 5, 2011·European Journal of Pain : EJP·Nadine AttalRolf-Detlef Treede
Jun 21, 2011·Experimental Neurology·Maija KalliomäkiTorsten Gordh
Oct 8, 2011·British Journal of Anaesthesia·K WildgaardH Kehlet

❮ Previous
Next ❯

Citations

Jan 23, 2014·Proceedings of the National Academy of Sciences of the United States of America·Kristian L HedstromGabriel Corfas
Feb 6, 2013·Acta Anaesthesiologica Scandinavica·K WildgaardH Kehlet
Mar 19, 2016·European Journal of Pain : EJP·G LandmannR Rukwied
Jul 30, 2014·European Journal of Pain : EJP·T SchlerethF Birklein
Sep 15, 2015·Pain Practice : the Official Journal of World Institute of Pain·Gunther LandmannRoman Rukwied
Sep 4, 2013·Pain·Christian GeberFrank Birklein
Sep 3, 2016·The Journal of Pain : Official Journal of the American Pain Society·Roger B FillingimRobert R Edwards
Oct 19, 2016·Pain·Christian Geber, Frank Birklein
Mar 16, 2018·Muscle & Nerve·Jenny L DaviesPeter J Dyck
Feb 26, 2020·European Journal of Pain : EJP·Scott F FarrellAnnina B Schmid
Apr 13, 2020·European Journal of Pain : EJP·Erik EllwardtFrank Birklein
Apr 23, 2016·Reviews on Environmental Health·Phillip J Albrecht, Frank L Rice
Jun 26, 2020·Physiological Reviews·Nanna Brix FinnerupTroels Staehelin Jensen
Jun 4, 2021·Joint, Bone, Spine : Revue Du Rhumatisme·Florian Bailly

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies
G CruccuR-D Treede
© 2021 Meta ULC. All rights reserved