Skin involvement in patients with psoriatic arthritis: preliminary results of treatment with apremilast in real world setting

Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia
Giulia RadiAnna Offidani

Abstract

Apremilast is a "small molecule," an oral phosphodiesterase 4 inhibitor indicated for the twice-daily treatment of adults with psoriasis and psoriatic arthritis (PsA). Data concerning clinical experience in real world setting with apremilast for psoriasis are still exiguous, and aim of this report is to provide our experience in the use of apremilast in out-patient setting. Ten Caucasian individuals (6 male, 4 females; mean age 69,3; range 53-81 years) affected by moderate to severe plaque psoriasis (PASI≥10 e/o DLQI≥10 e/O BSA≥10) were treated with apremilast, following dosing regimen of technical data sheet and clinically evaluated both after 12 weeks (T12) and 16 weeks (T16). At baseline median PASI was 14 (range 10-25, SD 5.0). The median BSA was 17.55 (10-25, SD 6.0), the median PGA was 3.5 (2-5, SD 1.1), the median DLQI was 7.3 (5-18, SD 3.6). The median absolute value of PASI, BSA, PGA and DLQI showed a statistically significant decrease (P<0.05) already after 12 weeks of treatment. At T12, 6 patients out of 10 (60%) reached PASI 50 and 3/10 patients (30%) reached PASI 75. At T16, 9 patients out of 10 patients (9/10, 90%) reached PASI75, and 3/10 (30%) reached PASI90. Five patients out of 10 (50%) reached MDA at T16. Dia...Continue Reading

References

Oct 28, 2008·Annals of the Rheumatic Diseases·C T RitchlinUNKNOWN Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA)
Oct 18, 2015·Rheumatic Diseases Clinics of North America·Wolf-Henning Boehncke
Mar 10, 2017·Expert Review of Clinical Pharmacology·Ramya Vangipuram, Ali Alikhan
Jun 10, 2017·American Journal of Clinical Dermatology·Tiago Torres, Luis Puig
Sep 20, 2017·Journal of the European Academy of Dermatology and Venereology : JEADV·I VujicL Richter
Dec 14, 2017·International Journal of Molecular Sciences·Yu Ri WooHyun Jeong Park

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Citations

Mar 18, 2020·Expert Opinion on Drug Safety·Anna CampanatiAnnamaria Offidani
May 20, 2020·Journal of the European Academy of Dermatology and Venereology : JEADV·A CampanatiA Offidani
Jun 18, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Tiago Torres
Feb 11, 2021·Toxins·Emanuela MartinaAnnamaria Offidani

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