Skin irritation induced by topically applied timolol

British Journal of Clinical Pharmacology
K KubotaK Yasuda

Abstract

1. Erythema induced by topically applied timolol, a non-selective beta-adrenoceptor blocker, was assessed in six male volunteers. Intensity of erythema developed on the inner surface of the left forearm where timolol free base was applied for 10 h was measured by a visual score, laser doppler flowmeter and reflectance spectrophotometry. Plasma timolol concentrations collected from the left and right arms were also measured. 2. The mean values for blood volume and blood flow per unit volume of tissue both of which were assessed by a laser doppler flowmeter, haemoglobin index measured by reflectance spectrophotometry, and magnitude of erythema graded by a visual score significantly increased after the application of an acrylic co-polymer adhesive patch containing 20% (w/v) timolol free base. 3. Plasma timolol concentrations collected from the left antecubital vein were 2.4 to 10.7 times greater than those from the right arm and had significant correlations (rs = 0.55 to 0.76) with the parameters indicating the extent of erythema developed where a patch containing timolol was applied. 4. The inter-individual variation of timolol was attributed to that of the diffusivity of timolol through skin rather than that of the skin reactivi...Continue Reading

References

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Citations

Jan 1, 1993·European Journal of Clinical Pharmacology·K KubotaT Ishizaki
Jul 29, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·R SutinenA Urtti
Apr 28, 2006·Expert Opinion on Drug Delivery·Mohammed AqilAsgar Ali
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Related Concepts

Administration, Topical
Erythema
Pustulants
Skin
Timoptol

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