Skin irritation: Reference chemicals data bank

Toxicology in Vitro : an International Journal Published in Association with BIBRA
D M BagleyA P Walker

Abstract

A list of 176 chemicals, all of high or consistent purity and stable on storage, has been developed using available comprehensive in vivo rabbit skin irritation data. No new in vivo testing was conducted to qualify a chemical for inclusion in the list. The chemicals were tested undiluted in in vivo studies, apart from those chemicals where high concentrations could be expected to cause severe effects. The in vivo data were generated in studies carried out since 1981 according to OECD Test Guideline 404 and following the principles of Good Laboratory Practice. The data were obtained from tests normally using at least three rabbits evaluated at the same time, involving application of 0.5 g or 0.5ml to the flank under semi-occlusive patches for 4 hr, and in which observations were made at least 24, 48 and 72 hr after removal of the patch. The chemicals represent a range of chemical classes [acids, acrylates/methacrylates, alcohols, aldehydes, alkalis, amines, brominated derivatives, chlorinated solvents, esters, ethers, fatty acids and mixtures, fragrance oils, halogenated aromatics, hydrocarbons (unsaturated), inorganics, ketones, nitrites, phenolic derivatives, S-containing compounds, soaps/surfactants, triglycerides] and differ...Continue Reading

References

Nov 1, 1992·Toxicology in Vitro : an International Journal Published in Association with BIBRA·D M BagleyA P Walker

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Citations

Oct 22, 2005·Toxicology and Applied Pharmacology·Sari PappinenArto Urtti
Apr 20, 2004·Toxicology Letters·Philip A Botham
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Nov 9, 2002·Toxicology in Vitro : an International Journal Published in Association with BIBRA·P PortesR Roguet
Mar 26, 2003·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J R HeylingsH M Owen
Aug 1, 1998·Toxicology in Vitro : an International Journal Published in Association with BIBRA·J H FentemM Liebsch
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Aug 22, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Matthieu RaouxMarcel Crest
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Jun 29, 2005·International Journal of Toxicology·UNKNOWN Cosmetic Ingredient Review Expert Panel
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Sep 7, 2020·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Wim H De JongKelly P Coleman
Mar 8, 2005·Regulatory Toxicology and Pharmacology : RTP·Sebastian HoffmannThomas Hartung
Nov 26, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Sharath GollaKhaled A M Gasem

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