Skin lesions in hereditary endocrine tumor syndromes.

Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists
Andrea Saggini, Maria Luisa Brandi

Abstract

To review the main cutaneous manifestations of hereditary endocrine tumor syndromes and discuss currently known molecular mechanisms involved in their pathogenesis. On the basis of our collective experience and a comprehensive MEDLINE literature search of the English-language literature published between January 1957 and September 2010 using the search terms "skin," "cutaneous," "multiple endocrine neoplasia," "Carney complex," and "McCune-Albright syndrome," we reviewed the dermatologic findings in multiple endocrine neoplasia type 1 and type 2, Carney complex, and McCune-Albright syndrome. Although the category of hereditary endocrine tumor syndromes consists of a broad spectrum of conditions, only the aforementioned few are prominently associated with cutaneous features. Because the cutaneous findings associated with these diseases are generally benign, they are often ignored or dismissed as ancillary findings in the context of severe systemic involvement. Accordingly, the pertinent literature is relatively scarce and often fails to provide a comprehensive insight about this issue. Nevertheless, timely recognition of such dermatologic manifestations may have a critical role in the early diagnosis and appropriate management o...Continue Reading

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Citations

Jul 12, 2012·Current Opinion in Pediatrics·Nicola A Quatrano, Karen J Loechner
Nov 14, 2013·Anesthesiology and Pain Medicine·James Adam RothschildMartin Slodzinski
Dec 13, 2016·Reviews in Endocrine & Metabolic Disorders·Constantine A Stratakis
Aug 28, 2020·Frontiers in Endocrinology·Maria TufanoStefano Stagi
Jul 12, 2017·American Journal of Clinical Dermatology·Yun TongPhilip R Cohen
Oct 8, 2020·The International Journal of Neuroscience·S ChatzikonstantinouS Bostanjopoulou

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