Skin markers of occult spinal dysraphism in children: a review of 54 cases

Archives of Dermatology
David GuggisbergDominique Hamel-Teillac

Abstract

To verify the diagnostic value of lumbosacral midline cutaneous lesions in asymptomatic children to detect occult spinal dysraphism (OSD) and to propose a practical approach for clinical investigations with respect to the type of cutaneous lesions observed. Retrospective study of 54 children referred to the Department of Pediatric Dermatology between 1990 and 1999 for congenital midline lumbosacral cutaneous lesions. The private or institutional practices of participating dermatologists and pediatricians. Evaluation of the diagnostic value of midline cutaneous lesions for the detec-tion of OSD. Association of skin examination findings with spinal anomalies detected by magnetic resonance imaging or ultrasound. Occult spinal dysraphism was detected in 3 of 36 patients with an isolated congenital midline lesion and 11 of 18 patients with a combination of 2 or more different skin lesions. A combination of 2 or more congenital midline skin lesions is the strongest marker of OSD. Careful dermatologic examination is needed to detect suggestive markers and request a spinal magnetic resonance image, which is the most sensitive radiologic approach to detect an OSD.

Citations

Jun 22, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Penina PongerShlomi Constantini
Oct 28, 2010·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Juan F Martínez-LageErnesto Domenech
Sep 10, 2013·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Akira GomiRieko Furukawa
Oct 1, 2008·World Journal of Pediatrics : WJP·Shigeo Iijima, Takehiko Ohzeki
Jul 11, 2009·Plastic and Reconstructive Surgery·Wai-Yee Li, John F Reinisch
Nov 27, 2007·Pediatric Dermatology·Tanda N Lane, Joshua E Lane
Mar 5, 2010·Pediatric Dermatology·Kabir SardanaVibhu Mendiratta
Sep 27, 2006·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Hosanna Au
Jun 1, 2011·Balkan Journal of Medical Genetics : BJMG·Dp NikolicR Karan
Mar 3, 2012·Journal of Neurosurgery. Pediatrics·Joshua J ChernJohn C Wellons
Oct 3, 2012·Neurosurgical Focus·Christina E SarrisChirag D Gandhi
Jul 1, 2009·Journal of Pediatric Neurosciences·Abdul Rashid BhatA U Ramzan
Jul 10, 2009·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·N Dallot-Le SachéS Renolleau
Jul 6, 2014·Pediatric Surgery International·Federico ScottoniPietro Bagolan
May 20, 2014·Journal of Neurosurgery. Pediatrics·Atsuko HaradaYukihiko Fujii
Aug 3, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Zelletta NicolaAntonio De Tommasi
Dec 17, 2009·AJNR. American Journal of Neuroradiology·R ThiexD B Orbach
Sep 11, 2010·The Journal of Pediatrics·Beth A DroletIlona J Frieden
Aug 1, 2009·The Journal of Pediatrics·Liat Ben-SiraShlomi Constantini
May 12, 2007·Neuroimaging Clinics of North America·John D Grimme, Mauricio Castillo
Nov 9, 2015·World Journal of Pediatrics : WJP·Mehmet Kenan Kanburoglu
Jun 15, 2005·Dermatologic Therapy·Davis FarvoldenKaren Wiss
Jul 30, 2014·International Journal of Dermatology·Yolanda Martínez-CriadoJose Bernabeu-Wittel
May 28, 2010·Journal of Cutaneous Pathology·Zeina TannousAbdul-Ghani Kibbi
Jul 6, 2014·Pediatric Radiology·Jennifer N KuceraBrian D Coley
Jun 18, 2016·International Journal of Dermatology·Alfons Krol
Jun 19, 2008·Journal of Pediatric Surgery·Ifeoma IkwuekeSara O Vargas
Apr 9, 2016·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M EliezerP-H Vivier
Nov 4, 2015·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M ZanelloF Di Rocco
Jun 9, 2015·Neurology India·Vipin K GuptaAshok K Attri
Jul 14, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·M PiramC Bodemer
Nov 30, 2007·Birth Defects Research. Part A, Clinical and Molecular Teratology·Julianne Byrne
Dec 8, 2005·American Journal of Medical Genetics. Part a·Julianne Byrne, Susan Carolan
Oct 28, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·E AusiliC Rendeli
Dec 4, 2019·Pediatrics in Review·Neha GuptaSergey Prokhorov
Apr 11, 2018·Pediatric Dermatology·Hima GopinathKaliaperumal Karthikeyan
Aug 10, 2019·BMC Neurology·Luca MassimiMassimo Caldarelli
Jan 6, 2015·Pediatric Dermatology·Matthew J SewellBeth A Drolet

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.