Skin microbiota-associated inflammation precedes autoantibody induced tissue damage in experimental epidermolysis bullosa acquisita

Journal of Autoimmunity
Christoph T EllebrechtJürgen Westermann

Abstract

Epidermolysis bullosa acquisita (EBA) is a chronic autoimmune blistering skin disease characterized by autoantibodies against type VII collagen (COL7). Immunization of SJL/J mice with recombinant murine COL7 results in break of tolerance and skin blisters. Strikingly, despite circulating autoantibodies, the same genetic background and identical environmental conditions, 20% of mice remain healthy. To elucidate the regulation of the transition from the presence of autoantibodies to overt autoimmune disease, we characterized the innate and adaptive immune response of mice that remain healthy after immunization and compared it to mice that developed skin disease. Both clinically healthy and diseased SJL/J mice showed circulating autoantibodies and deposition of complement-fixing IgG2c autoantibodies and C3 at the dermal-epidermal junction. However, only in diseased animals significant neutrophil infiltration and increase in FcgRIV expression were observed in the skin. In contrast, the expression of T cell signature cytokines in the T cell zone of the draining lymph node was comparable between clinically healthy and diseased animals after immunization. Surprisingly, health was associated with a decreased expression of CD11c, TNFA an...Continue Reading

References

May 1, 1990·Journal of Pharmacological Methods·C SchierwagenC Lundberg
Mar 1, 1988·The Journal of Clinical Investigation·D T WoodleyR A Briggaman
Sep 1, 1983·Annals of Internal Medicine·S SrikantaG S Eisenbarth
Apr 19, 1984·The New England Journal of Medicine·D T WoodleyW R Gammon
Jun 13, 2003·Pathologie-biologie·R M Steinman
May 12, 2004·Lancet·R Hal Scofield
Oct 19, 2004·Lancet·Alessandro VenturaDaniele Sblattero
Apr 21, 2005·The Journal of Clinical Investigation·Cassian SitaruDetlef Zillikens
Jul 26, 2005·Immunity·Falk NimmerjahnJeffrey V Ravetch
Mar 18, 2006·The Journal of Investigative Dermatology·David T WoodleyMei Chen
Aug 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Cassian SitaruDetlef Zillikens
Jun 26, 2007·Applied and Environmental Microbiology·Qiong WangJames R Cole
Sep 26, 2008·Archives of Dermatological Research·Agmon-Levin Nancy, Shoenfeld Yehuda
Aug 1, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Ashish V Chintakuntlawar, James Chodosh
Apr 13, 2010·Nature Methods·J Gregory CaporasoRob Knight
May 29, 2010·Diabetes Care·Mikael KnipHans K Akerblom
May 17, 2011·Cellular and Molecular Life Sciences : CMLS·Kristin J Ness-Schwickerath, Craig T Morita
May 25, 2011·Dermatologic Clinics·Ralf J Ludwig, Detlef Zillikens
Jun 28, 2011·Bioinformatics·Robert C EdgarRob Knight
Sep 29, 2011·Biochemical and Biophysical Research Communications·Yuko HaradaTohru Kataoka
Nov 9, 2011·Archives of Dermatological Research·Annika FahlénLionel Fry
Nov 10, 2011·Proceedings of the National Academy of Sciences of the United States of America·Philipp RauschJohn F Baines
Dec 14, 2011·The Journal of Allergy and Clinical Immunology·Thomas R AbrahamssonMaria C Jenmalm
May 9, 2012·Proceedings of the National Academy of Sciences of the United States of America·Ilkka HanskiTari Haahtela
Jun 14, 2012·The Journal of Pathology·Takashi HashimotoMinao Furumura
Jul 28, 2012·Science·Shruti NaikYasmine Belkaid

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Citations

Sep 1, 2016·Expert Review of Clinical Immunology·Artem VorobyevEnno Schmidt
Jun 21, 2017·Archives of Dermatological Research·Mia Maguire, Greg Maguire
Feb 21, 2019·Current Protocols in Pharmacology·Anika KasprickRalf J Ludwig
May 28, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Georg DaeschleinMichael Jünger
Jun 18, 2017·Frontiers in Immunology·Ralf J LudwigFalk Nimmerjahn
Jan 29, 2019·Frontiers in Medicine·Hiroshi KogaKatja Bieber
Jul 26, 2017·PeerJ·Melissa GardinerCatherine M Burke
Oct 12, 2018·International Journal of Molecular Sciences·David L VollmerEdwin D Lephart
Mar 23, 2017·Der Internist·T Schröder, S Ibrahim
Jul 8, 2020·The Journal of Allergy and Clinical Immunology·Johann E GudjonssonKilian Eyerich
Feb 27, 2021·Archives of Microbiology·Matina ZorbaFani Minti
Nov 11, 2019·Experimental and Molecular Pathology·Giovanni Luca ScaglioneEttore Capoluongo
Mar 9, 2021·Clinical and Experimental Dermatology·J BarL Samuelov

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