PMID: 8942394Nov 1, 1996Paper

Skin microcirculation of the foot in diabetic neuropathy

Clinical Science
P M NettenJ A Lutterman

Abstract

1. In the feet of patients with diabetic neuropathy, total skin blood flow is increased due to an increased shunt flow. The question is, does this increased anastomotic shunt flow lead to either under- or overperfused nutritive capillaries. 2. To solve this question, skin microcirculation tests of the left big toe were performed in 20 healthy control subjects and in 40 insulin-dependent diabetic patients without macroangiopathy, 20 without and 20 with neuropathy. Skin temperature measurements and laser Doppler fluxmetry were performed to record mainly shunt flow and capillaroscopy to study nailfold capillary blood flow. 3. The insulin-dependent diabetic patients with neuropathy had a higher baseline skin temperature (mean +/- SEM; 30.0 +/- 0.6 degrees C) and laser Doppler fluxmetry [26.2 +/- 2.2 perfusion units (pu)] than patients without neuropathy (27.2 +/- 0.8 degrees C, P < 0.01; 16.1 +/- 2.0 pu, P < 0.01) and healthy control subjects (27.9 +/- 0.7 degrees C, P < 0.05; 18.6 +/- 2.8 pu, P < 0.05). Sympathetic stimulation (inspiratory gasp) resulted in a smaller laser Doppler fluxmetry decrease in the neuropathic patients (31.4 +/- 4.6%) compared with non-neuropathic patients (48.2 +/- 5.1%, P < 0.05) and control subjects (49...Continue Reading

Citations

Nov 7, 2015·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Hyung Sub ParkTaeseung Lee
Oct 2, 2007·Explore : the Journal of Science and Healing·Arya NielsenTed J Kaptchuk
Feb 7, 2007·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Robert G FrykbergUNKNOWN American College of Foot and Ankle Surgeons
Aug 15, 2009·Diabetes/metabolism Research and Reviews·Clare Y L Chao, Gladys L Y Cheing
Jan 8, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·S BeckertS Coerper
Aug 6, 2010·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·S SangiorgiC Dell'Orbo
Jun 12, 2010·Microcirculation : the Official Journal of the Microcirculatory Society, Inc·Charumathi SabanayagamTien Yin Wong
Nov 28, 2013·Medical Hypotheses·Itay E GabbayUri Gabbay
Nov 28, 2002·Diabetes·Cees J TackDavid S Goldstein
Apr 29, 2016·Diabetologia·Fabio FiordalisoEzio Faglia
Oct 8, 2016·Clinical Hemorheology and Microcirculation·Z StoynevaE Titianova
Jan 3, 2001·British Journal of Clinical Pharmacology·A C Shore
Sep 5, 2002·Diabetic Medicine : a Journal of the British Diabetic Association·R DaviesS Brailsford
Oct 6, 2000·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·R M Bonelli, P Költringer
Jul 21, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Einar P Wilder-SmithYaling Guo
May 6, 2005·The International Journal of Lower Extremity Wounds·J Cobb, D Claremont
Nov 8, 2006·The International Journal of Lower Extremity Wounds·M BhararaD J Claremont
Aug 25, 2006·The International Journal of Lower Extremity Wounds·Anna Korzon-Burakowska, Michael Edmonds
Aug 25, 2006·The International Journal of Lower Extremity Wounds·M L IabichellaG Mosti
May 10, 2005·Diabetes/metabolism Research and Reviews·Nicola EberlRüdiger Landgraf
Apr 30, 2008·Diabetes/metabolism Research and Reviews·N C SchaperK Pickwell
Feb 24, 2005·Clinical Physiology and Functional Imaging·Harvey N Mayrovitz, Edye E Groseclose
Mar 20, 2008·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·L Joseph MeltonSundeep Khosla
Apr 28, 2004·Journal of Gerontological Nursing·Rosa Maria Berry, Edith D Hunt Raleigh
Sep 6, 2014·Current Diabetes Reports·Alin Stirban
Jan 1, 1998·European Psychiatry : the Journal of the Association of European Psychiatrists·M Knapp
Sep 22, 2020·American Journal of Physiology. Endocrinology and Metabolism·Raden ArgariniDaniel J Green

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.