PMID: 7543461Nov 1, 1994Paper

Skin microvascular architecture and perfusion studied in human postmastectomy oedema by intravital video-capillaroscopy

International Journal of Microcirculation, Clinical and Experimental
C C RobertsP S Mortimer

Abstract

Breast cancer treatment often causes chronic arm oedema. Oedema depends on the balance between microvascular filtration and lymph drainage, but little is known about the microvessels in postmastectomy oedema (PMO). We investigated cutaneous capillary density in PMO, since capillary density is one of the factors influencing fluid load on the lymphatic system. Video-capillaroscopy allows the skin microcirculation to be examined in vivo and recorded for later analysis. Patient arm volumes, measured optoelectronically, increased by 30 +/- 13%. The forearm skin of each arm was examined in 7 normal subjects (mean age 22 years) and 15 PMO patients (mean age 61 years). Native capillaroscopy was found to underestimate capillary density. Venous congestion increased the number of capillaries detected by native capillaroscopy by 26-28%. Fluorescein detected 19-27% more capillaries than native capillaroscopy. Using fluorescein, no significant difference in mean capillary density was found between the right (50 mm-2) and left (48 mm-2) arms of normal subjects (p = 0.53). Surprisingly, cutaneous capillary density in the swollen arm (33 mm-2) was not significantly less than in nonswollen arms (35 mm-2) of patients, despite a mean 14% increase ...Continue Reading

Citations

Dec 5, 2008·Breast Cancer Research and Treatment·Anthony W B StantonPeter S Mortimer
Dec 12, 2003·European Urology·A A OkekeD A Gillatt
May 19, 2007·Lymphatic Research and Biology·E I GalanzhaV P Zharov
Mar 24, 2009·Lymphatic Research and Biology·Anthony W B StantonPeter S Mortimer
May 18, 1999·Microvascular Research·A W StantonP S Mortimer
Jan 24, 2007·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Giuseppe Alessandro ScardinaPietro Messina
Jan 1, 2010·Clinical Physiology and Functional Imaging·Z A AwanK Kvernebo
Oct 9, 2002·Oncology Nursing Forum·Sheila H Ridner
Sep 6, 2000·The British Journal of Surgery·S J Pain, A D Purushotham
Dec 22, 1999·Clinical and Experimental Dermatology·S Hern, P S Mortimer
Apr 16, 1999·Hypertension·T F AntoniosG A MacGregor
Jul 2, 1999·Experimental Dermatology·A J BedlowP S Mortimer
Mar 16, 2005·Skin Pharmacology and Physiology·K Kretsos, G B Kasting

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