Skin necrosis after calcium hydroxylapatite injection into the glabellar and nasolabial folds

Ophthalmic Plastic and Reconstructive Surgery
Dan GeorgescuRichard L Anderson

Abstract

Calcium hydroxylapatite-induced skin necrosis occurred in 2 patients after injection in the glabella and the nasolabial fold, respectively. Supportive treatment with oral steroids, nitroglycerin paste, and warm compresses was initiated more than 48 hours after injection, and its role in recovery is uncertain. Both patients underwent microdermabrasion and used hydrocortisone ointment to flatten the scar, which resulted in gradual improvement with a reasonable cosmetic outcome 4 months after injection. This is the first report of calcium hydroxylapatite-induced skin necrosis. Injectors should be aware of this potential adverse event and counsel their patients appropriately.

References

May 10, 2002·The British Journal of Dermatology·S SchanzG Fierlbeck
Dec 22, 2007·Plastic and Reconstructive Surgery·Miles H GraivierThomas L Tzikas
May 21, 2008·Clinical Interventions in Aging·Patricio F Jacovella

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Citations

Aug 23, 2012·Facial Plastic Surgery Clinics of North America·Steven H DayanMary Lynn Moran
Oct 22, 2011·Clinics in Dermatology·Jason Emer, Heidi Waldorf
Apr 14, 2016·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Elie M Ferneini, Antoine M Ferneini
Jul 5, 2013·Aesthetic Surgery Journal·Cemile Nurdan OzturkJames E Zins
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Jul 16, 2014·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Claudio DeLorenzi
Mar 3, 2015·Plastic Surgical Nursing : Official Journal of the American Society of Plastic and Reconstructive Surgical Nurses·David Funt, Tatjana Pavicic
Oct 7, 2015·Plastic and Reconstructive Surgery·Berthold Rzany, Claudio DeLorenzi
Jun 17, 2015·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Gabriela Casabona

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