Skin phototype: a new perspective

Pigment Cell & Melanoma Research
Vittoria MarescaMauro Picardo

Abstract

Cutaneous phototype is considered mainly related to cutaneous pigmentation and to the eumelanin/pheomelanin ratio, which is mostly genetically determined by the melanocortin 1 receptor (MC1R) polymorphisms. However, data in literature indicate that, in addition to stimulation of eumelanin synthesis, the MC1R signalling activates antioxidant, DNA repair and survival pathways. New emerging aspects regarding photoprotection and skin phototypes are going beyond those features connected to the melanin content in the skin. Important new findings link the MC1R to nuclear receptors activation, shedding light on new extra-melanogenic effects dependent on the α-melanocyte-stimulating hormone (α-MSH) activity and new ways through which such functions are modulated. These evidences indicate that several factors including melanin play a part in defining the basis for individual sun sensitivity, suggesting that the cutaneous phototype represents a 'biochemical fingerprint'.

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Citations

Jul 28, 2016·Pigment Cell & Melanoma Research·Damilola Fajuyigbe, Antony R Young
Aug 29, 2016·Journal of Dermatological Science·Kyung-Il KimTae-Jin Yoon
Oct 12, 2016·Reviews in Endocrine & Metabolic Disorders·Christos C ZouboulisMarlon R Schneider
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May 12, 2017·Current Eye Research·Taylor NaymanMiguel N Burnier
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Dec 30, 2017·Pigment Cell & Melanoma Research·Thierry Passeron, Mauro Picardo
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Jan 4, 2020·Clinics in Dermatology·Vishal Gupta, Vinod Kumar Sharma
Apr 7, 2021·The Journal of Investigative Dermatology·Dongyoung LimJang-Hee Hahn
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