Skin prick test to egg white provides additional diagnostic utility to serum egg white-specific IgE antibody concentration in children

The Journal of Allergy and Clinical Immunology
Adina Kay KnightAnna Nowak-Wegrzyn

Abstract

Levels of IgE antibody to egg white of greater than 7 kIU/L are highly predictive of clinical reactivity to egg, and lower levels often require evaluation with oral food challenge (OFC) to establish definitive diagnosis. OFCs have inherent risks, and diagnostic criteria indicating high likelihood of passing would be clinically useful. We sought to determine whether the size of the skin prick test (SPT) to egg white adds diagnostic utility for children with low egg white-specific IgE antibody levels. A retrospective analysis of clinical history, egg white-specific IgE antibody levels, SPT responses, and egg OFC outcomes was performed. Children who passed (n = 29) egg OFCs and those who failed (n = 45) did not differ significantly in age, clinical characteristics, or egg white-specific IgE levels. There were, however, significant differences between both egg white SPT wheal response size and egg/histamine SPT wheal index. Children who failed egg OFCs had a median wheal of 5.0 mm; those who passed had a median wheal of 3.0 mm (P = .003). Children who failed egg OFCs had a median egg/histamine index of 1.00; those who passed had a median index of 0.71 (P = .001). For egg white-specific IgE levels of less than 2.5 kIU/L, an SPT whea...Continue Reading

Citations

Oct 6, 2010·Current Allergy and Asthma Reports·Jay A Lieberman, Scott H Sicherer
Sep 11, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Alexandra A HorwitzEjaz Yousef
Jan 6, 2009·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Linda CoxUNKNOWN American Academy of Allergy, Asthma and Immunology Specific IgE Test Task Force
Jun 4, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Vaishali S MankadA Wesley Burks
Jun 3, 2014·Current Pediatrics Reports·M Cecilia Berin
Jun 2, 2014·The Journal of Allergy and Clinical Immunology·Jean Christoph CaubetAnna Nowak-Węgrzyn
Dec 3, 2014·Immunology and Allergy Clinics of North America·Jacob D Kattan, Scott H Sicherer
Dec 1, 2009·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·John EckmanRobert G Hamilton
Aug 1, 2012·The Journal of Allergy and Clinical Immunology·Stephanie A LeonardAnna Nowak-Węgrzyn
Mar 15, 2012·Journal of Immunological Methods·Kirsi M Järvinen, Scott H Sicherer
Oct 30, 2010·The Journal of Pediatrics·David M FleischerDonald Y M Leung
Feb 16, 2010·The Journal of Pediatrics·Alyson B SimpsonJobayer Hossain
Apr 25, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·I Leonard BernsteinUNKNOWN American College of Allergy, Asthma and Immunology
Jan 1, 2010·The Journal of Allergy and Clinical Immunology·Scott H Sicherer, Hugh A Sampson
Oct 15, 2008·The Journal of Allergy and Clinical Immunology·Heather Lemon-MuléAnna Nowak-Wegrzyn
Aug 12, 2008·The Journal of Allergy and Clinical Immunology·Hitoshi AndoAtsuo Urisu
Jul 16, 2008·The Journal of Allergy and Clinical Immunology·Anna Nowak-WegrzynHugh A Sampson
Sep 25, 2007·The Journal of Pediatrics·David J HillJohn B Carlin
Apr 7, 2007·The Journal of Allergy and Clinical Immunology·Scott H Sicherer, Donald Y M Leung
Apr 30, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S TripodiP M Matricardi
Nov 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D J HillUNKNOWN EPAAC Study Group
Sep 22, 2007·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·S S TayP W Ewan
Jan 15, 2009·Clinical and Experimental Immunology·R SporikJ O'B Hourihane
Feb 4, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A SchroederX Wang
Apr 17, 2007·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Richard C NolanRichard K S Loh
Jan 26, 2013·Molecular Nutrition & Food Research·Franziska Roth-WalterTamar Kinaciyan
Jun 28, 2011·International Journal of Dermatology·Jarmila CelakovskáJaroslava Vaněčková
Dec 16, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C AlessandriA Mari
Apr 15, 2011·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A ClarkP Ewan
Jan 9, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M Vazquez-OrtizA M Plaza
Mar 10, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Jianmei ZhuSteven M Gendel
Feb 25, 2014·Allergology International : Official Journal of the Japanese Society of Allergology·Takanori ImaiMotohiro Ebisawa
Jan 13, 2015·The Journal of Allergy and Clinical Immunology. in Practice·J Andrew BirdTamara T Perry
Nov 5, 2013·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Steve L TaylorGeert Houben
Jun 5, 2012·The Journal of Allergy and Clinical Immunology·Jay A LiebermanAnna Nowak-Węgrzyn
Mar 8, 2011·The Journal of Allergy and Clinical Immunology·Audrey DunnGalvinJonathan O'B Hourihane
Mar 1, 2012·The Journal of Allergy and Clinical Immunology·A Wesley BurksHugh A Sampson
Sep 2, 2014·The Journal of Allergy and Clinical Immunology·Hugh A SampsonRobert Wood
Jun 16, 2009·The Journal of Allergy and Clinical Immunology·Anna Nowak-WegrzynUNKNOWN Adverse Reactions to Food Committee of American Academy of Allergy, Asthma & Immunology
Jan 4, 2012·Annals of Nutrition & Metabolism·Christophe Dupont
Dec 15, 2010·American Journal of Rhinology & Allergy·Jay A Lieberman, Scott H Sicherer
Jan 31, 2018·Allergy·M E PetterssonA E J Dubois
May 1, 2007·Pediatric Pulmonology·Alyson B SimpsonEjaz Yousef
Apr 17, 2009·Current Opinion in Allergy and Clinical Immunology·Dean Tey, Ralf G Heine
Oct 30, 2018·Clinical Reviews in Allergy & Immunology·Sara AnvariCarla M Davis

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