Skin Regeneration with a Scaffold of Predefined Shape and Bioactive Peptide Hydrogels

Tissue Engineering. Part a
Heejung ImYoungmee Jung

Abstract

We developed a highly elastic customized scaffold for soft tissue regeneration and combined them with bioactive hydrogels with stem cell-inducing ability. This was done to mimic mechanical properties of native soft tissues and improve the viability of transplanted cells as well as efficiency of tissue regeneration. The proposed study was aimed at evaluating various characteristics of scaffolds and investigating their tissue-regenerating ability. Finger-shaped porous scaffolds were successfully fabricated by an indirect 3D printing of poly (L-lactide-co-ɛ-caprolactone) (PLCL), which provides high elasticity for soft tissue engineering. In addition, a self-assembling peptide hydrogel coupled with substance P (RARADADARARADADA/RARADADARARADADA-substance P, RADA16/RADA16-SP) was used to accelerate angiogenesis and recruit intrinsic mesenchymal stem cells (MSCs). This study included three kinds of groups: Group I = PLCL scaffold with human dermal fibroblasts (HDFs) (P+C), Group II = PLCL scaffold with HDFs and RADA16 (P+C+R), and Group III = PLCL scaffold with HDFs, RADA16, and RADA16-SP (P+C+R+S). The samples were implanted into immunodeficient mice subcutaneously and harvested at 1 and 4 weeks. Tissue regeneration was evaluated by...Continue Reading

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Citations

Sep 28, 2018·Journal of Biomaterials Science. Polymer Edition·Mo LiZhiguo Chen
Mar 26, 2019·Advanced Materials·Benjamin R Freedman, David J Mooney
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Jul 2, 2019·Cells, Tissues, Organs·Alessia PaganelliCristina Magnoni

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Methods Mentioned

BETA
xenografts
bioprinting
scanning electron microscopy
Infrared Spectroscopy

Software Mentioned

GraphPad Prism
Image J

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