Skin-specific antibodies neutralizing mycolactone toxin during the spontaneous healing of Mycobacterium ulcerans infection

Science Advances
Mélanie FoulonEstelle Marion

Abstract

Buruli ulcer, a neglected tropical infectious disease, is caused by Mycobacterium ulcerans. Without treatment, its lesions can progress to chronic skin ulcers, but spontaneous healing is observed in 5% of cases, suggesting the possible establishment of a host strategy counteracting the effects of M. ulcerans. We reveal here a skin-specific local humoral signature of the spontaneous healing process, associated with a rise in antibody-producing cells and specific recognition of mycolactone by the mouse IgG2a immunoglobulin subclass. We demonstrate the production of skin-specific antibodies neutralizing the immunomodulatory activity of the mycolactone toxin, and confirm the role of human host machinery in triggering effective local immune responses by the detection of anti-mycolactone antibodies in patients with Buruli ulcer. Our findings pave the way for substantial advances in both the diagnosis and treatment of Buruli ulcer in accordance with the most recent challenges issued by the World Health Organization.

References

Jul 22, 1998·Journal of Immunological Methods·R M MartinA M Lew
Jan 22, 2008·The Journal of Allergy and Clinical Immunology·Dagmar SimonHans-Uwe Simon
Dec 17, 2008·Nature Reviews. Microbiology·Caroline DemangelStewart T Cole
Feb 10, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Rachel E SimmondsBrian M Foxwell
Apr 14, 2009·Clinics in Dermatology·Françoise PortaelsWayne M Meyers
Jan 14, 2010·Immunology·Naomi NishioKen-ichi Isobe
Oct 6, 2010·The Journal of Experimental Medicine·Nareen AbboudArturo Casadevall
May 9, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Skye A GeherinGudrun F Debes
May 1, 2013·Journal of Leukocyte Biology·Koichi YanabaShinichi Sato
Jul 11, 2013·Veterinary Immunology and Immunopathology·Skye A GeherinGudrun F Debes
Aug 12, 2014·The Lancet Global Health·Quentin B VincentAlexandre Alcaïs
Jan 27, 2015·Trends in Immunology·Isioma U EgbuniweKatie E Lacy
Feb 7, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Skye A GeherinGudrun F Debes
Feb 14, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Estelle MarionLaurent Marsollier
Mar 1, 2016·Open Forum Infectious Diseases·Estelle MarionLaurent Marsollier
Jun 14, 2017·European Journal of Immunology·Katharina PrachtWolfgang Schuh
Aug 9, 2017·European Journal of Immunology·Julie Tellier, Stephen L Nutt
Feb 20, 2019·PLoS Neglected Tropical Diseases·Daniel P O'BrienEugene Athan
Jun 4, 2019·The Journal of Investigative Dermatology·R Paul WilsonGudrun F Debes

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
flow cytometry
biopsy
biopsies
PCR

Software Mentioned

GraphPad Prism
MACSQuant

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Buruli ulcer is a progressive disease of subcutaneous tissues caused by mycobacterium ulcerans. Here is the latest research.

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