Skin test reactivity among Danish children measured 15 years apart

The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Simon Francis ThomsenVibeke Backer

Abstract

Knowledge of secular trends in the prevalence of allergy among children stems in large part from questionnaire surveys, whereas repeated cross-sectional studies using objective markers of atopic sensitization are sparse. To investigate whether the prevalence of skin prick test (SPT) positivity in Danish children has changed from 1986 to 2001. Serial cross-sectional studies of two different random population samples of children aged 7 to 17 years of age, living in urban Copenhagen, Denmark, were performed 15 years apart. The first cohort was investigated in 1986 (n = 527) and the second in 2001 (n = 480). Skin test reactivity to nine common aeroallergens was measured at both occasions. The prevalence of positive SPT to at least one allergen decreased from 24.1% in 1986 to 18.9% in 2001, (p = 0.05). We found a declining prevalence of sensitization to most allergens tested, statistically significant; however, only for mugwort and Alternaria iridis. Among subjects, who were sensitized to only one allergen, we found significantly fewer individuals with reactions to D. pteronyssinus and mugwort. The prevalence of atopic sensitization as judged by SPT positivity has decreased or remained unchanged among Danish children during the 15-y...Continue Reading

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Citations

Jul 7, 2009·The Journal of Allergy and Clinical Immunology·Eva RönmarkBo Lundbäck
Feb 4, 2012·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Anna Freyja FinnbogadóttirÁsgeir Haraldsson
Jan 25, 2011·Allergy·Tiina LaatikainenT Haahtela
Nov 14, 2016·The Journal of Allergy and Clinical Immunology. in Practice·Joakim BunneEva Rönmark
Sep 13, 2019·Allergy·Katja Biering Leth-MøllerAllan Linneberg
Oct 3, 2012·Journal of Biomolecular Structure & Dynamics·J Asnet MaryR Shenbagarathai
Oct 20, 2017·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Lukas B M Koet, Paul L P Brand
Dec 5, 2016·Allergologia et immunopathologia·E M Navarrete-RodríguezJ J L Sienra-Monge
Dec 18, 2020·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·Christine LoraudJocelyne Just
Sep 19, 2021·Acta Paediatrica·Arndís Rós StefánsdóttirÁsgeir Haraldsson

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