Skin testing and food challenges for the evaluation of food allergy

Current Allergy Reports
L W Williams

Abstract

Skin testing by prick technique has an excellent safety record in the evaluation of food hypersensitivity. Skin prick tests for the common food allergens are excellent tools for identifying those at very low risk of reaction on eating the food but are of variable value in identifying patients who will be positive on challenge. Intradermal skin tests to foods are less safe and appear to add no predictive information. Skin tests to less common food allergens, especially fruits, are less well characterized and may require use of the food item itself as the source of allergen rather than a commercial extract. For a few foods, the CAP system fluorescent enzyme immunoassay (Pharmacia, Peapack, NJ) recently has been shown to have good ability to identify patients at very high probability of reaction on oral challenge. Oral challenge remains the definitive method of demonstrating sensitivity or tolerance to a food. The double-blind, placebo-controlled food challenge is the gold standard of diagnosis, but in many situations, simpler open or single-blind challenge procedures may be substituted. With careful, incremental dosing and a low starting dose, oral challenges for food hypersensitivity have an excellent safety record. Skin prick t...Continue Reading

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Citations

Oct 31, 2007·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·De Yun WangKian Hian Yeoh
May 3, 2011·Hybridoma·Mohammad SoukhtanlooA-Reza Varasteh
May 24, 2012·Journal of Clinical Bioinformatics·Elena LópezJesús F Crespo
Apr 8, 2009·European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery·Ossama A HamidHatem Mosaad
Sep 2, 2009·The Korean Journal of Internal Medicine·Sae-Hoon KimYoon-Seok Chang
Jan 5, 2007·World Journal of Gastroenterology : WJG·Pasquale MansuetoGabriele Di Lorenzo
Feb 1, 2013·International Archives of Allergy and Immunology·Zdenek Pelikan

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