PMID: 6267115Sep 1, 1981Paper

Skin testing to detect penicillin allergy

The Journal of Allergy and Clinical Immunology
T J SullivanC W Parker

Abstract

Skin testing for penicillin allergy with penicillin G (Pen G), penicilloic acid (PA), and penicilloyl poly-L-lysine (PPL) was performed on 740 subjects, and the results were assessed from epidemiologic and immunologic perspectives. Approximately 95% of these patients had histories of apparent allergic reactions to beta-lactam antibiotics, and 63% were skin-test positive. The prevalence of positive skin tests was related to the time that had elapsed between clinical reactions and skin testing. Ninety-three percent were skin-test positive 7 to 12 mo after reactions, and 22% were positive 10 yr or more after reactions. Patients under 30 yr of age had a prevalence of positive skin tests 1.7-fold higher than older patients. Testing with PPL, PA, and Pen G detected 76.3%, 55.3%, and 57.1% of the positive patients, respectively. Omission of PPL, PA, or Pen G would have led to a failure to detect 25.6%, 7.2%, and 6.2% of the positive patients, respectively. Subjects with skin tests positive to penicillin often reacted to skin tests with other beta-lactam antibiotics; 73% (41 of 56) reacted to ampicillin and 51% (38 of 74) reacted to cephalothin. No serious allergic reactions were provoked by testing. None of the 83 skin test--negative ...Continue Reading

References

Aug 16, 1979·The New England Journal of Medicine·M ShapiroE H Kass
Jun 27, 1977·JAMA : the Journal of the American Medical Association·M CastleS Osterhout
Oct 1, 1973·The Journal of Infectious Diseases·B B Levine
Jul 1, 1971·The New England Journal of Medicine·N F AdkinsonL M Lichtenstein
Apr 1, 1969·The Journal of Allergy·B B Levine, D M Zolov
Jan 1, 1969·International Archives of Allergy and Applied Immunology·B B Levine, A P Redmond
Aug 20, 1955·British Medical Journal·B J O'DRISCOLL
Aug 24, 1964·JAMA : the Journal of the American Medical Association·B C BROWNM B MOORE
Nov 19, 1964·The New England Journal of Medicine·E ETTINGER, D KAYE
Oct 19, 1964·JAMA : the Journal of the American Medical Association·M A BUDDC W NORDEN

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Citations

Jan 1, 1994·Journal of Clinical Pharmacology·A G Recchia, N H Shear
Jan 1, 1986·Indian Journal of Pediatrics·R G EdwardsJ M Dewdney
Jan 1, 1985·Dermatologic Clinics·J Farnam, J A Grant
Dec 13, 2012·Current Allergy and Asthma Reports·Fatima S Khan, Michael E Weiss
Feb 1, 1982·The Journal of Allergy and Clinical Immunology·G O SolleyR G Van Dellen
Jan 1, 1984·The Journal of Allergy and Clinical Immunology·L M MendelsonJ E Selcow
May 1, 1986·The American Journal of Emergency Medicine·M R O'Leary, M S Smith
Jun 9, 1999·The Journal of Allergy and Clinical Immunology·A RomanoG Gasbarrini
Jul 2, 1988·Lancet·G PatriarcaE Romagna-Manoja
Feb 13, 2001·Toxicology·G Choquet-KastylevskyJ Descotes
Oct 6, 1998·Archives de pédiatrie : organe officiel de la Sociéte française de pédiatrie·M HervéP Reinert
Aug 30, 2006·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Benjamin B L WongSusan Waserman
Feb 8, 2008·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Arnon Goldberg, Ronit Confino-Cohen
Jul 27, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Miguel A ParkJames T C Li
Jan 5, 2007·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Barbara Capes JostGordon R Bloomberg
May 2, 2003·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Jeffrey S NugentTheodore M Freeman
Oct 13, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·R SolenskyR S Gruchalla
Dec 2, 2000·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·M A Valyasevi, R G Van Dellen
Oct 3, 1999·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·G PatriarcaA Milani
Jan 30, 2002·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Thomas C Puchner, Michael C Zacharisen
Jul 30, 2002·Allergy·Antonino RomanoM Blanca
Sep 20, 1984·The New England Journal of Medicine
May 9, 1985·The New England Journal of Medicine·G D WendelT J Sullivan
Apr 27, 1989·The New England Journal of Medicine·J E Slater
Sep 15, 2001·The New England Journal of Medicine·P S Kelkar, J T Li
Feb 15, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·E N PerencevichA D Harris
Sep 5, 2006·British Journal of Anaesthesia·R D MacPhersonA Wang
Oct 16, 2013·Current Opinion in Infectious Diseases·Jason Trubiano, Elizabeth Phillips
Mar 1, 1996·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·M BlancaC Juarez
Jul 1, 1993·International Journal of Dermatology·G SacerdotiV Ruocco
May 1, 1994·Allergy·J M VegaS Terrados
Jun 1, 1997·Archives of Disease in Childhood·A RomanoA Venuti
Feb 18, 1984·British Medical Journal·L Beeley
Apr 23, 1988·British Medical Journal·S J JachuckM Bryson
May 19, 2001·European Journal of Dermatology : EJD·F CousinJ F Nicolas
Aug 11, 2000·Paediatric Drugs·A Romano
May 27, 2014·Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology·Matthieu PicardAnne Des Roches
Mar 1, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·F LavaudC Ponvert
Jul 16, 2014·The Journal of Allergy and Clinical Immunology. in Practice·Stephanie J Fox, Miguel A Park
Sep 1, 1990·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·N F Adkinson
Jul 26, 2008·Journal of the American Pharmacists Association : JAPhA·Daryl D DePestelJames A Hadley
May 4, 2010·The Journal of Allergy and Clinical Immunology·Leticia Sánchez-MorillasLorena Morales Martínez

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